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Anti-WIPF1 Antibody

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产品名称: Anti-WIPF1 Antibody
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简单介绍

Anti-WIPF1 Antibody


Anti-WIPF1 Antibody  的详细介绍
Name: Anti-WIPF1 Antibody
See all WIPF1 primary antibodies
Description: Rabbit polyclonal antibody to WIPF1
Specificity: The antibody detects endogenous levels of total WIPF1 protein.
Applications: IHC
Reactivity: Human, Mouse
Immunogen: Synthetic peptide of human WIPF1
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification
Concentration: 0.7mg / ml
Formulation: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage: Store at -20?C
Function: Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus.
Tissue Specificity: Highly expressed in peripheral blood mononuclear cells, spleen, placenta, small intestine, colon and thymus. Lower expression in ovary, heart, brain, lung, liver, skeletal muscle, kidney, pancreas, prostate and testis.
Involvement in Disease: Wiskott-Aldrich syndrome 2: An immunodeficiency disorder characterized by eczema, thrombocytopenia, recurrent infections, defective T-cell proliferation, and impaired natural killer cell function.
Sequence Similarities: Belongs to the verprolin family.
Cellular Location: Cytoplasmic vesicle. Cytoplasm > Cytoskeleton. Cell projection > Ruffle.

Vesicle surfaces and along actin tails. Colocalizes with actin stress fibers. When coexpressed with WASL, no longer associated with actin filaments but accumulated in perinuclear and cortical areas like WASL (By similarity).
Database Links:
  • Entrez Gene: 7456?Human
  • Entrez Gene: 215280?Mouse
  • Omim: 602357?Human
  • SwissProt: O43516?Human
  • SwissProt: Q8K1I7?Mouse
  • Unigene: 128067?Human
  • Unigene: 223504?Mouse
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    Synonyms:
  • AI115543 Antibody
  • D2Ertd120e Antibody
  • MGC111041 Antibody
  • Protein PRPL-2 Antibody
  • PRPL 2 Antibody
  • PRPL-2 protein Antibody
  • WAS/WASL interacting protein family member 1 Antibody
  • WAS/WASL-interacting protein family member 1 Antibody
  • WAS2 Antibody
  • WASP-interacting protein Antibody
  • WASPIP Antibody
  • WIP Antibody
  • WIPF1 Antibody
  • WIPF1_HUMAN Antibody
  • Wiskott-Aldrich syndrome protein interacting protein Antibody
  • Wiskott-Aldrich syndrome protein-interacting protein Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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