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Anti-WEE1 (Phospho-Ser642) Antibody

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产品名称: Anti-WEE1 (Phospho-Ser642) Antibody
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Anti-WEE1 (Phospho-Ser642) Antibody


Anti-WEE1 (Phospho-Ser642) Antibody  的详细介绍
Name: Anti-WEE1 (Phospho-Ser642) Antibody
See all WEE1 primary antibodies
Description: Rabbit polyclonal antibody to WEE1 (Phospho-Ser642)
Specificity: The antibody detects endogenous levels of WEE1 only when phosphorylated at serine 642.
Applications: WB
Dilutions: Western blotting: 1:500~1:1000
Reactivity: Human, Mouse, Rat
Immunogen: Peptide sequence around phosphorylation site of Serine 642(S-V-S(p)-L-T) derived from Human WEE1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration: 1.0mg / ml
Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20˚C / 1 year
Function: Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.
Sequence Similarities: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
Post-Translational Modification: Phosphorylated during M and G1 phases. Also autophosphorylated. Phosphorylation at Ser-642 by BRSK1 and BRSK2 in post-mitotic neurons, leads to down-regulate WEE1 activity in polarized neurons. Phosphorylated at Ser-53 and Ser-123 by PLK1 and CDK1, respectively, generating an signal for degradation that can be recognized by the SCF(BTRC) complex, leading to its ubiquitination and degradation at the onset of G2/M phase.
Cellular Location: Nucleus.
Database Links:
  • Entrez Gene: 7465 Human
  • Entrez Gene: 22390 Mouse
  • Entrez Gene: 308937 Rat
  • Omim: 193525 Human
  • SwissProt: P30291 Human
  • SwissProt: P47810 Mouse
  • SwissProt: Q63802 Rat
  • Unigene: 249441 Human
  • Unigene: 287173 Mouse
  • Unigene: 208255 Rat
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    Synonyms:
  • DKFZp686I18166 Antibody
  • EC 2.7.10.2 Antibody
  • FLJ16446 Antibody
  • MGC105683 Antibody
  • OTTHUMP00000231338 Antibody
  • OTTHUMP00000231339 Antibody
  • Wee 1 Antibody
  • WEE 1 homolog 1 (S. pombe) Antibody
  • Wee1 Antibody
  • Wee1 homolog Antibody
  • WEE1 homolog (S. pombe) Antibody
  • WEE1 homolog S. pombe Antibody
  • Wee1 like protein kinase Antibody
  • Wee1 tyrosine kinase Antibody
  • Wee1+ homolog Antibody
  • Wee1+ S. pombe homolog Antibody
  • WEE1, S. pombe, homolog of Antibody
  • WEE1, somatic Antibody
  • Wee1-like protein kinase Antibody
  • WEE1A Antibody
  • Wee1A kinase Antibody
  • WEE1hu Antibody
  • WEE1_HUMAN Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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