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Anti-WDR45 Antibody

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产品名称: Anti-WDR45 Antibody
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Anti-WDR45 Antibody


Anti-WDR45 Antibody  的详细介绍
Name: Anti-WDR45 Antibody
See all WDR45 primary antibodies
Description: Rabbit polyclonal antibody to WDR45.
Applications: WB, IF
Dilutions: WB: 1:500 - 1:2000, IF: 1:50 - 1:100.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human WDR45.
Protein Length: 360
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Plays an important role in the autophagy pathway, which is the major intracellular degradation system by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation.
Tissue Specificity: Ubiquitously expressed, with high expression in skeletal muscle and heart. Weakly expressed in liver and placenta. Expression is down-regulated in pancreatic and in kidney tumors.
Involvement in Disease: Neurodegeneration with brain iron accumulation 5: A neurodegenerative disorder associated with iron accumulation in the brain, primarily in the basal ganglia. NBIA5 is characterized by global developmental delay in early childhood that is essentially static, with slow motor and cognitive gains until adolescence or early *****hood. In young *****hood, affected individuals develop progressive dystonia, parkinsonism, extrapyramidal signs, and dementia resulting in severe disability.
Sequence Similarities: Belongs to the WD repeat SVP1 family.
Database Links:
  • Entrez Gene: 11152 Human
  • Entrez Gene: 54636 Mouse
  • Omim: 300526 Human
  • SwissProt: Q9Y484 Human
  • SwissProt: Q91VM3 Mouse
  • Unigene: 632807 Human
  • Unigene: 305725 Mouse
    		•
    Synonyms:
  • JM5 Antibody
  • NBIA4 Antibody
  • WD repeat containing protein 45 Antibody
  • WD repeat domain 45 Antibody
  • WD repeat domain phosphoinositide interacting protein 4 Antibody
  • WD repeat domain, X linked 1 Antibody
  • WD45 repeat protein interacting with phosphoinositides 4 Antibody
  • WDR45 Antibody
  • WDRX1 Antibody
  • WDRXI4 Antibody
  • WIPI 4 Antibody
  • WIPI-4 Antibody
  • WIPI4 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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