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Anti-WDR41 Antibody

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产品名称: Anti-WDR41 Antibody
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Anti-WDR41 Antibody


Anti-WDR41 Antibody  的详细介绍
Name: Anti-WDR41 Antibody
See all WDR41 primary antibodies
Description: Rabbit polyclonal antibody to WDR41
Specificity: The antibody detects endogenous levels of total WDR41 protein.
Applications: IHC
Reactivity: Human
Immunogen: Fusion protein of human WDR41
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 0.7mg / ml
Formulation: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage: Store at -20?C
Function: Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity (PubMed:27103069, PubMed:27617292).
Cellular Location: Cytoplasm.
Database Links:
  • Entrez Gene: 55255?Human
  • SwissProt: Q9HAD4?Human
  • Unigene: 482573?Human
    		•
    Synonyms:
  • FLJ10904 Antibody
  • MSTP048 Antibody
  • WD repeat domain 41 Antibody
  • WD repeat protein 41 Antibody
  • WD repeat-containing protein 41 Antibody
  • WDR 41 Antibody
  • WDR41 Antibody
  • WDR41_HUMAN Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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