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Anti-WDR35 Antibody

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产品名称: Anti-WDR35 Antibody
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Anti-WDR35 Antibody


Anti-WDR35 Antibody  的详细介绍
Name: Anti-WDR35 Antibody
See all WDR35 primary antibodies
Description: Rabbit polyclonal antibody to WDR35
Specificity: WDR35 antibody is human specific.
Applications: E, IHC
Reactivity: Human
Immunogen: 16 amino acid peptide near the amino terminus of human WDR35.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Affinity chromatography purified via peptide column
Formulation: PBS containing 0.02% sodium azide.
Storage: Store at 4?C for three months and -20?C, stable for up to one year.
Function: Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Required for ciliogenesis. May promote CASP3 activation and TNF-stimulated apoptosis.
Involvement in Disease: Cranioectodermal dysplasia 2: A disorder characterized by craniofacial, skeletal and ectodermal abnormalities. Clinical features include short stature, dolichocephaly, craniosynostosis, narrow thorax with pectus excavatum, short limbs, brachydactyly, joint laxity, narrow palpebral fissures, telecanthus with hypertelorism, low-set simple ears, everted lower lip, and short neck. Teeth abnormalities include widely spaced, hypoplastic and fused teeth.

Short-rib thoracic dysplasia 7 with or without polydactyly: A form of short-rib thoracic dysplasia, a group of autosomal recessive ciliopathies that are characterized by a constricted thoracic cage, short ribs, shortened tubular bones, and a 'trident' appearance of the acetabular roof. Polydactyly is variably present. Non-skeletal involvement can include cleft lip/palate as well as anomalies of major organs such as the brain, eye, heart, kidneys, liver, pancreas, intestines, and genitalia. Some forms of the disease are lethal in the neonatal period due to respiratory insufficiency secondary to a severely restricted thoracic cage, whereas others are compatible with life. Disease spectrum encompasses Ellis-van Creveld syndrome, asphyxiating thoracic dystrophy (Jeune syndrome), Mainzer-Saldino syndrome, and short rib-polydactyly syndrome. SRTD7 hallmarks are acromesomelic hypomineralization, campomelia, polysyndactyly, laterality defects, and cystic kidneys.
Cellular Location: Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Cytoplasm > Cytoskeleton > Cilium axoneme. Cytoplasm > Cytoskeleton > Cilium basal body.
Database Links:
  • Entrez Gene: 57539?Human
  • Omim: 613602?Human
  • SwissProt: Q9P2L0?Human
  • Unigene: 205427?Human
    		•
    Synonyms:
  • Intraflagellar transport protein 121 homolog Antibody
  • KIAA1336 Antibody
  • MGC33196 Antibody
  • Naofen Antibody
  • WD repeat domain 35 Antibody
  • WD repeat-containing protein 35 Antibody
  • WDR35 Antibody
  • WDR35_HUMAN Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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