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Anti-WDFY2 Antibody

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产品名称: Anti-WDFY2 Antibody
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简单介绍

Anti-WDFY2 Antibody


Anti-WDFY2 Antibody  的详细介绍
Name: Anti-WDFY2 Antibody
See all WDFY2 primary antibodies
Description: Rabbit polyclonal antibody to WDFY2.
Applications: WB
Dilutions: WB: 1:500 - 1:2000.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human WDFY2.
Protein Length: 400
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (PubMed:17313651). Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1 (PubMed:18388859). Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By similarity). Participates in transferrin receptor endocytosis (PubMed:16873553).
Cellular Location: Endosome. Early endosome. Cytoplasm.

Localizes to intracellular vesicles (PubMed:16792529). Colocalizes with VAMP2 and PRKCZ in intracellular vesicles (PubMed:17313651). Colocalizes with AKT2 in early endosomes (By similarity).
Database Links:
  • Entrez Gene: 115825 Human
  • Entrez Gene: 268752 Mouse
  • Omim: 610418 Human
  • SwissProt: Q96P53 Human
  • SwissProt: Q8BUB4 Mouse
  • Unigene: 208550 Human
  • Unigene: 482243 Mouse
    		•
    Synonyms:
  • PROF Antibody
  • Propeller-FYVE protein Antibody
  • RP11 147H23.1 Antibody
  • WD repeat and FYVE domain containing 2 Antibody
  • WD repeat and FYVE domain-containing protein 2 Antibody
  • WD40 and FYVE domain containing 2 Antibody
  • WD40- and FYVE domain-containing protein 2 Antibody
  • WDF2 Antibody
  • WDFY2 Antibody
  • WDFY2_HUMAN Antibody
  • ZFYVE22 Antibody
  • Zinc finger FYVE domain-containing protein 22 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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