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Anti-WBP7 Antibody

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产品名称: Anti-WBP7 Antibody
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简单介绍

Anti-WBP7 Antibody


Anti-WBP7 Antibody  的详细介绍
Name: Anti-WBP7 Antibody
See all WBP7 primary antibodies
Description: Rabbit polyclonal antibody to WBP7
Specificity: WBP7 pAb detects endogenous levels of WBP7 protein.
Applications: WB
Reactivity: Human, Mouse, Rat
Immunogen: A synthetic peptide corresponding to residues in Human WBP7.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 36, 294 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Function: Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2. Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development. Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation.
Tissue Specificity: Widely expressed. Highest levels in testis. Also found in brain, bone marrow, heart, muscle, kidney, placenta, spleen, thymus, prostate, ovary, intestine, colon, peripheral blood lymphocytes and pancreas. Often amplified in pancreatic carcinomas.
Sequence Similarities: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.
Cellular Location: Nucleus.
Database Links:
  • Entrez Gene: 9757 Human
  • Entrez Gene: 75410 Mouse
  • Entrez Gene: 102550344 Rat
  • Omim: 606834 Human
  • SwissProt: Q9UMN6 Human
  • SwissProt: O08550 Mouse
  • Unigene: 676457 Human
  • Unigene: 92236 Human
  • Unigene: 168688 Mouse
    		•
    Synonyms:
  • Histone-lysine N-methyltransferase 2B Antibody
  • HRX2 Antibody
  • KIAA0304 gene product Antibody
  • KMT2B Antibody
  • KMT2B / MLL4 Antibody
  • KMT2B_HUMAN Antibody
  • Likely ortholog of mouse WW domain binding protein 7 Antibody
  • Lysine N-methyltransferase 2B Antibody
  • mixed lineage leukemia 4 Antibody
  • Mixed lineage leukemia gene homolog 2 protein Antibody
  • MLL2 Antibody
  • myeloid lymphoid leukemia 4 Antibody
  • Myeloid lymphoid or mixed lineage leukemia protein 4 Antibody
  • Myeloid/lymphoid or mixed-lineage leukemia protein 4 Antibody
  • Trithorax homolog 2 Antibody
  • trithorax homologue 2 Antibody
  • TRX2 Antibody
  • WBP-7 Antibody
  • WBP7 Antibody
  • WW domain-binding protein 7 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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