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Anti-VTCN1 Antibody

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产品名称: Anti-VTCN1 Antibody
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简单介绍

Anti-VTCN1 Antibody


Anti-VTCN1 Antibody  的详细介绍
Name: Anti-VTCN1 Antibody
See all VTCN1 primary antibodies
Description: Goat polyclonal antibody to VTCN1.
Applications: ELISA, WB
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human VTCN1 (internal region).
Sequence: C-PEVNVDYNASSET
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 µg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
Tissue Specificity: Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis.
Sequence Similarities: Belongs to the immunoglobulin superfamily. BTN/MOG family.
Post-Translational Modification: N-glycosylated.
Cellular Location: Cell membrane.

Expressed at the cell surface. A soluble form has also been detected.
Database Links:
  • Entrez Gene: 79679 Human
  • Omim: 608162 Human
  • SwissProt: Q7Z7D3 Human
  • Unigene: 546434 Human
    		•
    Synonyms:
  • B7 family member, H4 Antibody
  • B7 H4 Antibody
  • B7 homolog 4 Antibody
  • B7 superfamily member 1 Antibody
  • B7 superfamily, member 1 Antibody
  • B7-H4 Antibody
  • B7h.5 Antibody
  • B7H4 Antibody
  • B7S1 Antibody
  • B7x Antibody
  • BC032925 Antibody
  • Immune costimulatory protein B7-H4 Antibody
  • Immune costimulatory protein B7H4 Antibody
  • MGC41287 Antibody
  • PRO1291 Antibody
  • Protein B7S1 Antibody
  • RP11 229A19.4 Antibody
  • T cell costimulatory molecule B7x Antibody
  • T-cell costimulatory molecule B7x Antibody
  • V set domain-containing T cell activation inhibitor 1 Antibody
  • V-set domain-containing T-cell activation inhibitor 1 Antibody
  • VCTN1 Antibody
  • Vtcn1 Antibody
  • VTCN1_HUMAN Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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