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Anti-VRK2 Antibody

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产品名称: Anti-VRK2 Antibody
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简单介绍

Anti-VRK2 Antibody


Anti-VRK2 Antibody  的详细介绍
Name: Anti-VRK2 Antibody
See all VRK2 primary antibodies
Description: Goat polyclonal antibody to VRK2.
Applications: ELISA, WB
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human VRK2 (internal region).
Sequence: C-PNSQKVDSQKAATK
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 µg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant.
Tissue Specificity: Isoform 1 and isoform 2 are expressed in various tumor cell lines. Expression of isoform 1 inversely correlates with ERBB2 in breast carcinomas (at protein level). Widely expressed. Highly expressed in fetal liver, skeletal muscle, pancreas, heart, peripheral blood leukocytes and testis.
Sequence Similarities: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.
Post-Translational Modification: Isoform 1 and isoform 2 are autophosphorylated.
Cellular Location: Cytoplasm. Endoplasmic reticulum membrane. Mitochondrion membrane.
Database Links:
  • Entrez Gene: 7444 Human
  • Omim: 602169 Human
  • SwissProt: Q86Y07 Human
  • Unigene: 728198 Human
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    Synonyms:
  • 2810003O05Rik Antibody
  • AI447698 Antibody
  • EC 2.7.11.1 Antibody
  • Serine/threonine protein kinase VRK2 Antibody
  • Serine/threonine-protein kinase VRK2 Antibody
  • Vaccinia related kinase 2 Antibody
  • Vaccinia virus B1R related kinase 2 Antibody
  • Vaccinia-related kinase 2 Antibody
  • VRK 2 Antibody
  • VRK2 Antibody
  • VRK2_HUMAN Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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