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Anti-VR1 (Phospho-Ser503) Antibody

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产品名称: Anti-VR1 (Phospho-Ser503) Antibody
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Anti-VR1 (Phospho-Ser503) Antibody


Anti-VR1 (Phospho-Ser503) Antibody  的详细介绍
Name: Anti-VR1 (Phospho-Ser503) Antibody
See all VR1 primary antibodies
Description: Rabbit Polycolonal antibody to VR1 (Phospho-Ser503)
Specificity: VR1 (Phospho-Ser503) Antibody detects endogenous levels of VR1 only when phosphorylated at Ser503
Applications: WB
Reactivity: Mouse, Rat
Immunogen: A synthesized peptide derived from human VR1 (Phospho-Ser503)
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration: 1.0mg / ml
Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20˚C
Function: Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.
Tissue Specificity: Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level).
Sequence Similarities: Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV1 sub-subfamily.
Post-Translational Modification: Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites, probably including Ser-117 as a major phosphorylation site. Phosphorylation by CAMKII seems to regulate binding to vanilloids. Phosphorylated and modulated by PRKCE, PRKCM and probably PRKCZ. Dephosphorylation by calcineurin seems to lead to receptor desensitization and phosphorylation by CAMKII recovers activity.
Cellular Location: Cell junction > Synapse > Postsynaptic cell membrane. Cell projection > Dendritic spine membrane. Cell membrane.

Mostly, but not exclusively expressed in postsynaptic dendritic spines.
Database Links:
  • Entrez Gene: 193034 Mouse
  • Entrez Gene: 83810 Rat
  • SwissProt: Q704Y3 Mouse
  • SwissProt: O35433 Rat
  • Unigene: 447485 Mouse
  • Unigene: 3073 Rat
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    Synonyms:
  • Capsaicin receptor Antibody
  • DKFZp434K0220 Antibody
  • osm 9 like TRP channel 1 Antibody
  • Osm-9-like TRP channel 1 Antibody
  • OTRPC1 Antibody
  • Transient receptor potential cation channel subfamily V member 1 Antibody
  • TRPV 1 Antibody
  • Trpv1 Antibody
  • TRPV1_HUMAN Antibody
  • Vanilloid receptor 1 Antibody
  • Vanilloid receptor subtype 1 Antibody
  • VR 1 Antibody
  • VR1 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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