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Anti-HER4 (Phospho-Tyr1284) Antibody

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产品名称: Anti-HER4 (Phospho-Tyr1284) Antibody
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Anti-HER4 (Phospho-Tyr1284) Antibody


Anti-HER4 (Phospho-Tyr1284) Antibody  的详细介绍
Name: Anti-HER4 (Phospho-Tyr1284) Antibody
See all HER4 primary antibodies
Description: Rabbit polyclonal antibody to HER4 (Phospho-Tyr1284)
Specificity: The antibody detects endogenous level of p38 HER4 only when phosphorylated at Tyrosine 1284.
Applications: WB
Reactivity: Human, Mouse, Rat
Immunogen: Peptide sequence around phosphorylation site of Tyrosine 1284 (P-E-Y(p)-L-S) derived from Human HER4
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration: 1.0mg / ml
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20˚C / 1 year
Function: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as s for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis.
Tissue Specificity: Expressed at highest levels in brain, heart, kidney, in addition to skeletal muscle, parathyroid, cerebellum, pituitary, spleen, testis and breast. Lower levels in thymus, lung, salivary gland, and pancreas. Isoform JM-A CYT-1 and isoform JM-B CYT-1 are expressed in cerebellum, but only the isoform JM-B is expressed in the heart.
Involvement in Disease: Amyotrophic lateral sclerosis 19: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.
Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Post-Translational Modification: Isoform JM-A CYT-1 and isoform JM-A CYT-2 are processed by ADAM17. Proteolytic processing in response to ligand or 12-O-tetradecanoylphorbol-13-acetate stimulation results in the production of 120 kDa soluble receptor forms and intermediate membrane-anchored 80 kDa fragments (m80HER4), which are further processed by a presenilin-dependent gamma-secretase to release a cytoplasmic intracellular domain (E4ICD; E4ICD1/s80Cyt1 or E4ICD2/s80Cyt2, depending on the isoform). Membrane-anchored 80 kDa fragments of the processed isoform JM-A CYT-1 are more readily degraded by the proteasome than fragments of isoform JM-A CYT-2, suggesting a prevalence of E4ICD2 over E4ICD1. Isoform JM-B CYT-1 and isoform JM-B CYT-2 lack the ADAM17 cleavage site and are not processed by ADAM17, precluding further processing by gamma-secretase.
Cellular Location: Cell membrane.

In response to NRG1 treatment, the activated receptor is internalized.
Database Links:
  • Entrez Gene: 2066 Human
  • Entrez Gene: 13869 Mouse
  • Entrez Gene: 59323 Rat
  • Omim: 600543 Human
  • SwissProt: Q15303 Human
  • SwissProt: Q61527 Mouse
  • SwissProt: Q62956 Rat
  • Unigene: 390729 Human
  • Unigene: 442420 Mouse
  • Unigene: 163078 Rat
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    Synonyms:
  • 4ICD Antibody
  • ALS19 Antibody
  • Avian erythroblastic leukemia viral oncogene homolog 4 Antibody
  • Avian erythroblastic leukemia viral v erb b2 oncogene homolog 4 Antibody
  • E4ICD Antibody
  • EC 2.7.10.1 Antibody
  • ErbB 4 Antibody
  • Erbb4 Antibody
  • ERBB4 intracellular domain Antibody
  • ERBB4_HUMAN Antibody
  • HER 4 Antibody
  • HER4 Antibody
  • human epidermal growth factor receptor 4 Antibody
  • Mer4 Antibody
  • MGC138404 Antibody
  • Oncogene ERBB4 Antibody
  • p180erbB4 Antibody
  • Proto-oncogene-like protein c-ErbB-4 Antibody
  • Receptor protein tyrosine kinase erbB 4 precursor Antibody
  • Receptor tyrosine protein kinase erbB 4 Antibody
  • s80HER4 Antibody
  • Tyrosine kinase type cell surface receptor HER4 Antibody
  • Tyrosine kinase-type cell surface receptor HER4 Antibody
  • v erb a avian erythroblastic leukemia viral oncogene homolog like 4 Antibody
  • v erb a erythroblastic leukemia viral oncogene homolog 4 Antibody
  • v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) Antibody
  • V-ERB-B2 avian erythroblastic leukemia viral oncogene homolog 4 Antibody
  • Verba avian erythroblastic leukemia viral oncogene homolog like 4 Antibody
  • Verba erythroblastic leukemia viral oncogene homolog 4 Antibody
  • VERBB2 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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