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Anti-Heparin-binding growth factor 2 Antibody

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产品名称: Anti-Heparin-binding growth factor 2 Antibody
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Anti-Heparin-binding growth factor 2 Antibody


Anti-Heparin-binding growth factor 2 Antibody  的详细介绍
Name: Anti-Heparin-binding growth factor 2 Antibody
See all Heparin-binding growth factor 2 primary antibodies
Description: Rabbit polyclonal antibody to Heparin-binding growth factor 2
Specificity: The antibody detects endogenous level of total Heparin-binding growth factor 2 polyclonal antibody.
Applications: WB, IHC
Reactivity: Mouse
Immunogen: Recombinant Mouse Heparin-binding growth factor 2 protein
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Caprylic Acid Ammonium Sulfate Precipitation purified
Concentration: 1.0mg / mL
Formulation: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Storage: Store at -20?C
Function: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Can induce angiogenesis (PubMed:23469107).
Tissue Specificity: Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue.
Sequence Similarities: Belongs to the heparin-binding growth factors family.
Post-Translational Modification: Phosphorylation at Tyr-215 regulates FGF2 unconventional secretion.
Cellular Location: Secreted. Nucleus.

Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane. Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57.
Database Links:
  • Entrez Gene: 14173?Mouse
  • SwissProt: P15655?Mouse
  • Unigene: 473689?Mouse
    		•
    Synonyms:
  • Basic fibroblast growth factor Antibody
  • Basic fibroblast growth factor bFGF Antibody
  • BFGF Antibody
  • FGF 2 Antibody
  • FGF B Antibody
  • FGF-2 Antibody
  • FGF2 Antibody
  • FGF2 basic Antibody
  • FGF2_HUMAN Antibody
  • FGFB Antibody
  • Fibroblast growth factor 2 Antibody
  • Fibroblast growth factor 2 (basic) Antibody
  • Fibroblast growth factor, basic Antibody
  • HBGF 2 Antibody
  • HBGF-2 Antibody
  • HBGF2 Antibody
  • HBGH 2 Antibody
  • HBGH2 Antibody
  • Heparin binding growth factor 2 precursor Antibody
  • Heparin-binding growth factor 2 Antibody
  • Prostatropin Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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