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Anti-HELLS Antibody

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产品名称: Anti-HELLS Antibody
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简单介绍

Anti-HELLS Antibody


Anti-HELLS Antibody  的详细介绍
Name: Anti-HELLS Antibody
See all HELLS primary antibodies
Description: Rabbit polyclonal antibody to HELLS
Specificity: HELLS pAb detects endogenous levels of HELLS protein.
Applications: WB, IHC, IF, IP, CHIP
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human HELLS.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 91 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.
Function: Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity).
Tissue Specificity: Highly expressed in proliferative tissues such as ***** thymus and testis, and expressed at lower levels in uterus, small intestine, colon, and peripheral blood mononuclear cells. Also expressed in neoplastic cell lines including those derived from myeloid and lymphoid leukemias.
Involvement in Disease: Immunodeficiency-centromeric instability-facial anomalies syndrome 4: A rare disorder characterized by a variable immunodeficiency resulting in recurrent infections, facial anomalies, and branching of chromosomes 1, 9, and 16. Other variable symptoms include growth retardation, failure to thrive, and psychomotor retardation. Laboratory studies show limited hypomethylation of DNA in a small fraction of the genome in some, but not all, patients.
Sequence Similarities: Belongs to the SNF2/RAD54 helicase family.
Cellular Location: Nucleus.

Closely associated with pericentric heterochromatin.
Database Links:
  • Entrez Gene: 3070?Human
  • Entrez Gene: 15201?Mouse
  • GenBank: AAH30963?Human
  • Omim: 603946?Human
  • SwissProt: Q9NRZ9?Human
  • SwissProt: Q60848?Mouse
  • Unigene: 655830?Human
    		•
    Synonyms:
  • FLJ10339 Antibody
  • Helicase lymphoid specific Antibody
  • Hells Antibody
  • HELLS_HUMAN Antibody
  • LSH Antibody
  • Lymphoid specific helicase Antibody
  • Lymphoid-specific helicase Antibody
  • Nbla10143 Antibody
  • PASG Antibody
  • Proliferation associated SNF2 like protein Antibody
  • Proliferation-associated SNF2-like protein Antibody
  • SMARCA6 Antibody
  • SWI/SNF2 related matrix associated actin dependent regulator of chromatin subfamily A member 6 Antibody
  • SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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