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Anti-HEF1 Antibody

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产品名称: Anti-HEF1 Antibody
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简单介绍

Anti-HEF1 Antibody


Anti-HEF1 Antibody  的详细介绍
Name: Anti-HEF1 Antibody
See all HEF1 primary antibodies
Description: Rabbit polyclonal antibody to HEF1
Specificity: The antibody detects endogenous levels of total HEF1 protein.
Applications: WB
Reactivity: Mouse
Immunogen: Recombinant fragment contain a sequence corresponding to a region within amino acids 115 and 444 of HEF1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were purified by antigen-affinity chromatography.
Concentration: 0.93mg / ml
Formulation: Rabbit IgG in 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage: Store at -20˚C
Function: Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form.
Tissue Specificity: Widely expressed. Higher levels detected in kidney, lung, and placenta. Also detected in T-cells, B-cells and diverse cell lines. The protein has been detected in lymphocytes, in diverse cell lines, and in lung tissues.
Sequence Similarities: Belongs to the CAS family.
Post-Translational Modification: Cell cycle-regulated processing produces four isoforms: p115, p105, p65, and p55. Isoform p115 arises from p105 phosphorylation and appears later in the cell cycle. Isoform p55 arises from p105 as a result of cleavage at a caspase cleavage-related site and it appears specifically at mitosis. The p65 isoform is poorly detected.
Cellular Location: Cytoplasm > Cell cortex. Nucleus. Golgi apparatus. Cell projection > Lamellipodium. Cytoplasm. Cell junction > Focal adhesion.

Localizes to both the cell nucleus and the cell periphery and is differently localized in fibroblasts and epithelial cells. In fibroblasts is predominantly nuclear and in some cells is present in the Golgi apparatus. In epithelial cells localized predominantly in the cell periphery with particular concentration in lamellipodia but is also found in the nucleus. Isoforms p105 and p115 are predominantly cytoplasmic and associate with focal adhesions while p55 associates with mitotic spindle.
Database Links:
  • Entrez Gene: 18003 Mouse
  • SwissProt: O35177 Mouse
    		•
    Synonyms:
  • Cas like docking Antibody
  • Cas scaffolding protein family member 2 Antibody
  • CAS-L Antibody
  • CAS2 Antibody
  • CasL Antibody
  • CASL_HUMAN Antibody
  • CASS2 Antibody
  • Crk associated substrate related Antibody
  • Crk associated substrate related protein Antibody
  • CRK-associated substrate-related protein Antibody
  • dJ49G10.2 Antibody
  • dJ49G10.2 (Enhancer of Filamentation 1 (HEF1)) Antibody
  • dJ761I2.1 Antibody
  • dJ761I2.1 (enhancer of filamentation (HEF1)) Antibody
  • Enhancer of filamentation 1 Antibody
  • Enhancer of filamentation 1 p55 Antibody
  • HEF 1 Antibody
  • HEF1 Antibody
  • NEDD-9 Antibody
  • Nedd9 Antibody
  • Neural precursor cell expressed developmentally down-regulated protein 9 Antibody
  • P105 Antibody
  • Renal carcinoma antigen NY-REN-12 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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