产品资料

Anti-HEC1 Antibody

如果您对该产品感兴趣的话,可以
产品名称: Anti-HEC1 Antibody
产品型号:
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

Anti-HEC1 Antibody


Anti-HEC1 Antibody  的详细介绍
Name: Anti-HEC1 Antibody
See all HEC1 primary antibodies
Description: Rabbit polyclonal antibody to HEC1
Specificity: HEC1 pAb detects endogenous levels of HEC1 protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human HEC1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 74 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.
Function: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:9315664, PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327). Required for kinetochore integrity and the organization of stable microtubule s in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:25743205, PubMed:23891108).
Sequence Similarities: Belongs to the NDC80/HEC1 family.
Post-Translational Modification: Phosphorylation begins in S phase of the cell cycle and peaks in mitosis. Phosphorylated by NEK2. May also be phosphorylated by AURKA and AURKB.
Cellular Location: Nucleus. Chromosome > Centromere > Kinetochore.

Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore.
Database Links:
  • Entrez Gene: 10403?Human
  • Entrez Gene: 67052?Mouse
  • Entrez Gene: 301701?Rat
  • Omim: 607272?Human
  • SwissProt: O14777?Human
  • SwissProt: Q9D0F1?Mouse
  • Unigene: 414407?Human
  • Unigene: 225956?Mouse
  • Unigene: 225213?Rat
    		•
    Synonyms:
  • from Entrez Gene ; Antibody
  • HEC Antibody
  • HEC1 Antibody
  • Highly expressed in cancer Antibody
  • Highly expressed in cancer protein Antibody
  • Highly expressed in cancer rich in leucine heptad repeats Antibody
  • HsHec1 Antibody
  • hsNDC80 Antibody
  • Kinetochore associated 2 Antibody
  • Kinetochore associated protein 2 Antibody
  • Kinetochore protein Hec1 Antibody
  • Kinetochore protein NDC80 homolog Antibody
  • Kinetochore-associated protein 2 Antibody
  • KNTC2 Antibody
  • ndc80 Antibody
  • NDC80 homolog kinetochore complex component Antibody
  • NDC80 kinetochore complex component homolog Antibody
  • NDC80, S. cerevisiae, homolog of Antibody
  • NDC80_HUMAN Antibody
  • Retinoblastoma associated protein HEC Antibody
  • Retinoblastoma-associated protein HEC Antibody
  • TID3 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
    产品留言
    标题
    联系人
    联系电话
    内容
    验证码
    点击换一张
    注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
    2.如有必要,请您留下您的详细联系方式!

    沪公网安备 31011202007337号