Anti-Heat shock protein 75 kDa, mitochondrial Antibody

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产品名称: Anti-Heat shock protein 75 kDa, mitochondrial Antibody

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Anti-Heat shock protein 75 kDa, mitochondrial Antibody 的详细介绍

Name:	Anti-Heat shock protein 75 kDa, mitochondrial Antibody See all Heat shock protein 75 kDa, mitochondrial primary antibodies
Description:	Rabbit polyclonal antibody to Heat shock protein 75 kDa, mitochondrial
Specificity:	The antibody detects endogenous level of total Heat shock protein 75 kDa, mitochondrial polyclonal antibody.
Applications:	WB
Reactivity:	Human
Immunogen:	Recombinant human Heat shock protein 75 kDa, mitochondrial protein
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Caprylic Acid Ammonium Sulfate Precipitation purified
Concentration:	1.0mg / mL
Formulation:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Storage:	Store at -20˚C

Function:	Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.
Tissue Specificity:	Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder. Expression is higly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but it is increased in other type of tumors.
Sequence Similarities:	Belongs to the heat shock protein 90 family.
Cellular Location:	Mitochondrion. Mitochondrion inner membrane. Mitochondrion matrix.
Database Links:	Entrez Gene: 10131 Human Omim: 606219 Human SwissProt: Q12931 Human Unigene: 30345 Human
Synonyms:	Heat shock protein 75 kDa Antibody Heat shock protein 75 kDa, mitochondrial Antibody HSP 75 Antibody HSP75 Antibody HSP90L Antibody mitochondrial Antibody TNF receptor associated protein 1 Antibody TNFR-associated protein 1 Antibody TRAP-1 Antibody TRAP1 Antibody TRAP1_HUMAN Antibody Tumor necrosis factor type 1 receptor-associated protein Antibody
Information:	Target information shown above is from the UniProt Consortium.

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