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Anti-HDAC8 Antibody

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产品名称: Anti-HDAC8 Antibody
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Anti-HDAC8 Antibody


Anti-HDAC8 Antibody  的详细介绍
Name: Anti-HDAC8 Antibody
See all HDAC8 primary antibodies
Description: Rabbit polyclonal antibody to HDAC8.
Applications: WB, IP
Dilutions: WB: 1:500 - 1:2000, IP: 1:20 - 1:100.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human HDAC8.
Protein Length: 377
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility.
Tissue Specificity: Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney.
Involvement in Disease: Cornelia de Lange syndrome 5: A form of Cornelia de Lange syndrome, a clinically heterogeneous developmental disorder associated with malformations affecting multiple systems. It is characterized by facial dysmorphisms, abnormal hands and feet, growth delay, cognitive retardation, hirsutism, gastroesophageal dysfunction and cardiac, ophthalmologic and genitourinary anomalies.

Wilson-Turner X-linked mental retardation syndrome: A neurologic disorder characterized by severe intellectual disability, dysmorphic facial features, hypogonadism, short stature, and truncal obesity. Affected females have a milder phenotype than affected males.
Sequence Similarities: Belongs to the histone deacetylase family. HD type 1 subfamily.
Post-Translational Modification: Phosphorylated by PKA on serine 39. Phosphorylation reduces deacetylase activity observed preferentially on histones H3 and H4.
Cellular Location: Nucleus. Cytoplasm.

Excluded from the nucleoli. Found in the cytoplasm of cells showing smooth muscle differentiation.
Database Links:
  • Entrez Gene: 55869 Human
  • Entrez Gene: 70315 Mouse
  • Entrez Gene: 363481 Rat
  • Omim: 300269 Human
  • SwissProt: Q9BY41 Human
  • SwissProt: Q8VH37 Mouse
  • SwissProt: B1WC68 Rat
  • Unigene: 310536 Human
  • Unigene: 328128 Mouse
  • Unigene: 208476 Rat
    		•
    Synonyms:
  • CDA07 Antibody
  • CDLS5 Antibody
  • HD 8 Antibody
  • HD8 Antibody
  • HDAC 8 Antibody
  • HDAC8 Antibody
  • HDAC8_HUMAN Antibody
  • HDACL 1 Antibody
  • HDACL1 Antibody
  • Histone deacetylase 8 Antibody
  • Histone deacetylase like 1 Antibody
  • MRXS6 Antibody
  • RPD 3 Antibody
  • RPD3 Antibody
  • WTS Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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