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Anti-HDAC7A (Phospho-Ser155) Antibody

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产品名称: Anti-HDAC7A (Phospho-Ser155) Antibody
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Anti-HDAC7A (Phospho-Ser155) Antibody


Anti-HDAC7A (Phospho-Ser155) Antibody  的详细介绍
Name: Anti-HDAC7A (Phospho-Ser155) Antibody
See all HDAC7A primary antibodies
Description: Rabbit polyclonal antibody to HDAC7A (Phospho-Ser155)
Specificity: The antibody detects endogenous levels of HDAC7A only when phosphorylated at serine 155.
Applications: WB
Dilutions: Western blotting: 1:500~1:1000
Reactivity: Human, Mouse
Immunogen: Peptide sequence around phosphorylation site of Serine 155(T-V-S(p)-E-P) derived from Human HDAC7A.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration: 1.0mg / ml
Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20˚C / 1 year
Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565).
Sequence Similarities: Belongs to the histone deacetylase family. HD type 2 subfamily.
Post-Translational Modification: May be phosphorylated by CaMK1. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. Phosphorylation at Ser-155 by MARK2, MARK3 and PRKD1 promotes interaction with 14-3-3 proteins and export from the nucleus. Phosphorylation at Ser-155 is a prerequisite for phosphorylation at Ser-181.
Cellular Location: Nucleus. Cytoplasm.

In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation.
Database Links:
  • Entrez Gene: 51564 Human
  • Entrez Gene: 56233 Mouse
  • Omim: 606542 Human
  • SwissProt: Q8WUI4 Human
  • SwissProt: Q8C2B3 Mouse
  • Unigene: 200063 Human
  • Unigene: 384027 Mouse
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    Synonyms:
  • DKFZP586J0917 Antibody
  • FLJ99588 Antibody
  • HD 7a Antibody
  • HD7 Antibody
  • HD7a Antibody
  • HDAC 7 Antibody
  • HDAC 7A Antibody
  • HDAC7 Antibody
  • HDAC7A Antibody
  • HDAC7_HUMAN Antibody
  • Histone deacetylase 7 Antibody
  • Histone deacetylase 7A Antibody
  • OTTHUMP00000202813 Antibody
  • OTTHUMP00000202814 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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