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Anti-HDAC6 (Phospho-Ser22) Antibody

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产品名称: Anti-HDAC6 (Phospho-Ser22) Antibody
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Anti-HDAC6 (Phospho-Ser22) Antibody


Anti-HDAC6 (Phospho-Ser22) Antibody  的详细介绍
Name: Anti-HDAC6 (Phospho-Ser22) Antibody
See all HDAC6 primary antibodies
Description: Rabbit polyclonal antibody to HDAC6 (Phospho-Ser22)
Specificity: The antibody detects endogenous level of HDAC6 only when phosphorylated at serine 22.
Applications: WB
Reactivity: Human, Mouse
Immunogen: Peptide sequence around phosphorylation site of serine 22 (P-Q-S(p)-P-P) derived from Human HDAC6.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration: 1.0mg / ml
Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20˚C / 1 year
Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Involvement in Disease: Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia: A disease characterized by chondrodysplasia, severe platyspondyly, hydrocephaly, and facial features with microphthalmia. Bone abnormalities include a distinctive metaphyseal cupping of the metacarpals, metatarsals, and phalanges. Affected females show a milder phenotype with small stature, sometimes associated with body asymmetry and mild mental retardation.
Sequence Similarities: Belongs to the histone deacetylase family. HD type 2 subfamily.
Post-Translational Modification: Phosphorylated by AURKA.
Cellular Location: Nucleus. Cytoplasm. Perikaryon. Cell projection > Dendrite. Cell projection > Axon.

It is mainly cytoplasmic, where it is associated with microtubules.
Database Links:
  • Entrez Gene: 10013 Human
  • Entrez Gene: 15185 Mouse
  • Omim: 300272 Human
  • SwissProt: Q9UBN7 Human
  • SwissProt: Q9Z2V5 Mouse
  • Unigene: 6764 Human
  • Unigene: 29854 Mouse
    		•
    Synonyms:
  • CPBHM Antibody
  • FLJ16239 Antibody
  • HD 6 Antibody
  • HD6 Antibody
  • HDAC 6 Antibody
  • HDAC6 Antibody
  • HDAC6_HUMAN Antibody
  • Histone deacetylase 6 Antibody
  • Histone deacetylase 6 (HD6) Antibody
  • JM 21 Antibody
  • JM21 Antibody
  • KIAA0901 Antibody
  • OTTHUMP00000032398 Antibody
  • OTTHUMP00000197663 Antibody
  • PPP1R90 Antibody
  • Protein phosphatase 1 regulatory subunit 90 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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