产品资料

Anti-HDAC5 Antibody

如果您对该产品感兴趣的话,可以
产品名称: Anti-HDAC5 Antibody
产品型号:
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

Anti-HDAC5 Antibody


Anti-HDAC5 Antibody  的详细介绍
Name: Anti-HDAC5 Antibody
See all HDAC5 primary antibodies
Description: Rabbit polyclonal antibody to HDAC5.
Applications: WB, IHC
Dilutions: WB: 1:500 - 1:1000, IHC: 1:50 - 1:100.
Reactivity: Human
Immunogen: A synthetic peptide of human HDAC5.
Protein Length: 1122
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Tissue Specificity: Ubiquitous.
Sequence Similarities: Belongs to the histone deacetylase family. HD type 2 subfamily.
Post-Translational Modification: Phosphorylated by AMPK, CaMK1, SIK1 and PRKD1 at Ser-259 and Ser-498. The phosphorylation is required for the export to the cytoplasm and inhibition. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. Phosphorylated by GRK5, leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription (By similarity).
Cellular Location: Nucleus. Cytoplasm.

Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by AMPK, CaMK1 and SIK1.
Database Links:
  • Entrez Gene: 10014?Human
  • Omim: 605315?Human
  • SwissProt: Q9UQL6?Human
  • Unigene: 438782?Human
    		•
    Synonyms:
  • Antigen NY CO 9 Antibody
  • Antigen NY-CO-9 Antibody
  • HD5 Antibody
  • HDAC 5 Antibody
  • HDAC5 Antibody
  • HDAC5_HUMAN Antibody
  • Histone deacetylase 5 Antibody
  • NY CO 9 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
    产品留言
    标题
    联系人
    联系电话
    内容
    验证码
    点击换一张
    注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
    2.如有必要,请您留下您的详细联系方式!

    沪公网安备 31011202007337号