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Anti-HDAC3 Antibody

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产品名称: Anti-HDAC3 Antibody
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Anti-HDAC3 Antibody


Anti-HDAC3 Antibody  的详细介绍
Name: Anti-HDAC3 Antibody
See all HDAC3 primary antibodies
Description: Rabbit polyclonal antibody to HDAC3
Specificity: The antibody detects endogenous levels of total HDAC3 protein.
Applications: IF, WB
Reactivity: Human
Immunogen: Recombinant fragment corresponding to a region within amino acids 128 and 428 of HDAC3.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were purified by antigen-affinity chromatography.
Concentration: 0.91mg / ml
Formulation: Rabbit IgG in 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage: Store at -20˚C
Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803).
Tissue Specificity: Widely expressed.
Sequence Similarities: Belongs to the histone deacetylase family. HD type 1 subfamily.
Post-Translational Modification: Sumoylated in vitro.
Cellular Location: Nucleus. Cytoplasm. Cytoplasm > Cytosol.

Colocalizes with XBP1 and AKT1 in the cytoplasm (PubMed:25190803). Predominantly expressed in the nucleus in the presence of CCAR2.
Database Links:
  • Entrez Gene: 8841 Human
  • Omim: 605166 Human
  • SwissProt: O15379 Human
  • Unigene: 519632 Human
    		•
    Synonyms:
  • HD3 Antibody
  • HDAC 3 Antibody
  • HDAC3 Antibody
  • HDAC3_HUMAN Antibody
  • Histone deacetylase 3 Antibody
  • RPD3 Antibody
  • RPD3 2 Antibody
  • RPD3-2 Antibody
  • SMAP45 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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