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Anti-HDAC2 Antibody

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产品名称: Anti-HDAC2 Antibody
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Anti-HDAC2 Antibody


Anti-HDAC2 Antibody  的详细介绍
Name: Anti-HDAC2 Antibody
See all HDAC2 primary antibodies
Description: Rabbit polyclonal antibody to HDAC2.
Applications: WB, IHC, IF, IP, FC
Dilutions: WB: 1:500 - 1:2000.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human HDAC2.
Protein Length: 488
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.
Tissue Specificity: Widely expressed; lower levels in brain and lung.
Sequence Similarities: Belongs to the histone deacetylase family. HD type 1 subfamily.
Post-Translational Modification: S-nitrosylated by GAPDH. In neurons, S-Nitrosylation at Cys-262 and Cys-274 does not affect the enzyme activity but abolishes chromatin-binding, leading to increases acetylation of histones and activate genes that are associated with neuronal development. In embryonic cortical neurons, S-Nitrosylation regulates dendritic growth and branching. S-Nitrosylation interferes with its interaction with MTA1 (By similarity).
Cellular Location: Nucleus. Cytoplasm.
Database Links:
  • Entrez Gene: 3066?Human
  • Entrez Gene: 15182?Mouse
  • Entrez Gene: 84577?Rat
  • Omim: 605164?Human
  • SwissProt: Q92769?Human
  • SwissProt: P70288?Mouse
  • Unigene: 3352?Human
  • Unigene: 19806?Mouse
  • Unigene: 1797?Rat
    		•
    Synonyms:
  • D10Wsu179e Antibody
  • HD 2 Antibody
  • HD2 Antibody
  • HDAC 2 Antibody
  • HDAC2 Antibody
  • HDAC2_HUMAN Antibody
  • Histone deacetylase 2 Antibody
  • Histone deacetylase 2 (HD2) Antibody
  • OTTHUMP00000017046 Antibody
  • OTTHUMP00000227077 Antibody
  • OTTHUMP00000227078 Antibody
  • RPD3 Antibody
  • transcriptional regulator homolog RPD3 Antibody
  • YAF1 Antibody
  • YY1 associated factor 1 Antibody
  • YY1 transcription factor binding protein Antibody
  • Yy1bp Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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