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Anti-SEPT9 Antibody

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产品名称: Anti-SEPT9 Antibody
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简单介绍

Anti-SEPT9 Antibody


Anti-SEPT9 Antibody  的详细介绍
Name: Anti-SEPT9 Antibody
See all SEPT9 primary antibodies
Description: Rabbit polyclonal antibody to SEPT9
Specificity: The antibody detects endogenous levels of total SEPT9 Antibody.
Applications: IHC
Dilutions: Immunohistochemistry: 1:15-1:50
Reactivity: Human
Immunogen: Fusion protein corresponding to residues near the C terminal of human septin 9
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 0.6mg / ml
Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage: Store at -20?C
Function: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.
Tissue Specificity: Widely expressed. Isoforms are differentially expressed in testes, kidney, liver heart, spleen, brain, peripheral blood leukocytes, skeletal muscle and kidney. Specific isoforms appear to demonstrate tissue specificity. Isoform 5 is the most highly expressed in fetal tissue. Isoform 1 is detected in all tissues except the brain and thymus, while isoform 2, isoform 3, and isoform 4 are detected at low levels in approximately half of the fetal tissues.
Involvement in Disease: Hereditary neuralgic amyotrophy: Autosomal dominant form of recurrent focal neuropathy characterized clinically by acute, recurrent episodes of brachial plexus neuropathy with muscle weakness and atrophy preceded by severe pain in the affected arm. HNA is triggered by environmental factors such as infection or parturition.
Sequence Similarities: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
Cellular Location: Cytoplasm > Cytoskeleton.

In an epithelial cell line, concentrates at cell-cell contact areas. After TGF-beta1 treatment and induction of epithelial to mesenchymal transition, colocalizes partly with actin stress fibers. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria.
Database Links:
  • Entrez Gene: 10801?Human
  • Omim: 604061?Human
  • SwissProt: Q9UHD8?Human
  • Unigene: 440932?Human
    		•
    Synonyms:
  • AF17q25 Antibody
  • Cell division control protein septin D1 Antibody
  • KIAA0991 Antibody
  • MLL septin like fusion protein Antibody
  • MLL septin-like fusion protein Antibody
  • MLL septin-like fusion protein MSF-A Antibody
  • MSF Antibody
  • MSF1 Antibody
  • NAPB Antibody
  • Ov/Br septin Antibody
  • Ovarian/Breast septin Antibody
  • Ovarian/breast septin alpha Antibody
  • PNUTL4 Antibody
  • SEPT9 Antibody
  • SEPT9_HUMAN Antibody
  • SeptD1 Antibody
  • Septin 9 Antibody
  • Septin D1 Antibody
  • Septin-9 Antibody
  • SINT1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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