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Anti-SEPT4 Antibody

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产品名称: Anti-SEPT4 Antibody
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简单介绍

Anti-SEPT4 Antibody


Anti-SEPT4 Antibody  的详细介绍
Name: Anti-SEPT4 Antibody
See all SEPT4 primary antibodies
Description: Rabbit polyclonal antibody to SEPT4
Applications: ELISA, WB, IHC
Reactivity: Human
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Affinity purified
Concentration: 1.0mg / ml
Formulation: PBS, pH 7.4 with 0.02% Sodium Azide
Storage: This product is stable for several weeks at 4?C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20?C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Function: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli.
Tissue Specificity: Widely expressed in ***** and fetal tissues with highest expression in ***** brain (at protein level), heart, liver and adrenal gland and fetal heart, kidney, liver and lung. Also expressed in colorectal cancers and malignant melanomas. Expressed in platelets.
Sequence Similarities: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
Cellular Location: Cytoplasm. Cytoplasm > Cytoskeleton. Cell projection > Cilium > Flagellum.

In platelets, found in areas surrounding alpha-granules. Found in the sperm annulus (PubMed:25588830).
Database Links:
  • Entrez Gene: 5414?Human
  • Omim: 603696?Human
  • SwissProt: O43236?Human
  • Unigene: 287518?Human
    		•
    Synonyms:
  • Apoptosis-related protein in the TGF-beta signaling pathway Antibody
  • ARTS Antibody
  • Bradeion Antibody
  • Bradeion beta Antibody
  • Brain protein H5 Antibody
  • CE5B3 Antibody
  • CE5B3 beta Antibody
  • Cell division control-related protein 2 Antibody
  • Cerebral protein 7 Antibody
  • H5 Antibody
  • hCDCREL-2 Antibody
  • hucep-7 Antibody
  • MART Antibody
  • Peanut-like protein 2 Antibody
  • PNUTL2 Antibody
  • SEP 4 Antibody
  • SEP4 Antibody
  • SEPT4 Antibody
  • SEPT4_HUMAN Antibody
  • Septin M Antibody
  • Septin-4 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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