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Anti-ROR alpha Antibody

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产品名称: Anti-ROR alpha Antibody
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Anti-ROR alpha Antibody


Anti-ROR alpha Antibody  的详细介绍
Name: Anti-ROR alpha Antibody
See all ROR alpha primary antibodies
Description: Rabbit polyclonal antibody to ROR alpha
Specificity: The antibody detects endogenous levels of total ROR alpha protein.
Applications: WB
Reactivity: Human, Mouse
Immunogen: Synthetic peptide corresponding to a region within amino acids 157 and 252 of ROR alpha.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were purified by antigen-affinity chromatography.
Concentration: 1mg / ml
Formulation: Rabbit IgG in 1XPBS, 1%BSA, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage: Store at -20˚C
Function: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target genes regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates genes involved in photoreceptor development including OPN1SW, OPN1SM and ARR3 and skeletal muscle development with MYOD1. Required for proper cerebellum development, regulates SHH gene expression, among others, to induce granule cells proliferation as well as expression of genes involved in calcium-mediated signal transduction. Regulates the circadian expression of several clock genes, including CLOCK, ARNTL/BMAL1, NPAS2 and CRY1. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORA-mediated activation of clock genes expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Regulates genes involved in lipid metabolism such as apolipoproteins APOA1, APOA5, APOC3 and PPARG. In liver, has specific and redundant functions with RORC as positive or negative modulator of expression of genes encoding phase I and phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as CYP7B1 and SULT2A1. Induces a rhythmic expression of some of these genes. In addition, interplays functionally with NR1H2 and NR1H3 for the regulation of genes involved in cholesterol metabolism. Also involved in the regulation of hepatic glucose metabolism through the modulation of G6PC and PCK1. In adipose tissue, plays a role as negative regulator of adipocyte differentiation, probably acting through dual mechanisms. May suppress CEBPB-dependent adipogenesis through direct interaction and PPARG-dependent adipogenesis through competition for DNA-binding. Downstream of IL6 and TGFB and synergistically with RORC isoform 2, is implicated in the lineage specification of uncommitted CD4(+) T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program. Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus. Involved in hypoxia signaling by interacting with and activating the transcriptional activity of HIF1A. May inhibit cell growth in response to cellular stress. May exert an anti-inflammatory role by inducing CHUK expression and inhibiting NF-kappa-B signaling.
Tissue Specificity: Widely expressed in a number of tissues. Expressed in both regulatory T-cells (Treg) and effector T-cells (Teff).
Sequence Similarities: Belongs to the nuclear hormone receptor family. NR1 subfamily.
Post-Translational Modification: Phosphorylation by conventional PKCs in neurons inhibits transcriptional activity. Phosphorylated on Thr-183 by MAPK1/ERK1 in vitro.
Cellular Location: Nucleus.
Database Links:
  • Entrez Gene: 6095 Human
  • Entrez Gene: 19883 Mouse
  • Omim: 600825 Human
  • SwissProt: P35398 Human
  • SwissProt: P51448 Mouse
  • Unigene: 560343 Human
  • Unigene: 655155 Human
  • Unigene: 378450 Mouse
  • Unigene: 391890 Mouse
  • Unigene: 427266 Mouse
  • Unigene: 490614 Mouse
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    Synonyms:
  • fhl2a Antibody
  • NR1F1 Antibody
  • Nuclear receptor ROR-alpha Antibody
  • Nuclear receptor RZR-alpha Antibody
  • Nuclear receptor subfamily 1 group F member 1 Antibody
  • RAR-related orphan receptor A Antibody
  • Retinoid-related orphan receptor-alpha Antibody
  • ROR alpha Antibody
  • Rora Antibody
  • RORA_HUMAN Antibody
  • RZR-ALPHA Antibody
  • RZRA Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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