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Anti-ROCK2 Antibody

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产品名称: Anti-ROCK2 Antibody
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简单介绍

Anti-ROCK2 Antibody


Anti-ROCK2 Antibody  的详细介绍
Name: Anti-ROCK2 Antibody
See all ROCK2 primary antibodies
Description: Rabbit polyclonal antibody to ROCK2
Specificity: The antibody detects endogenous level of total ROCK2 protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human ROCK2.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were purified by affinity purification using immunogen.
Concentration: 1.0mg / ml
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20?C
Function: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation.
Sequence Similarities: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Post-Translational Modification: Phosphorylation at Tyr-722 reduces its binding to RHOA and is crucial for focal adhesion dynamics. Dephosphorylation by PTPN11 stimulates its RHOA binding activity.
Cellular Location: Cytoplasm. Cell membrane. Nucleus. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome.

Cytoplasmic, and associated with actin microfilaments and the plasma membrane.
Database Links:
  • Entrez Gene: 9475?Human
  • Entrez Gene: 19878?Mouse
  • Entrez Gene: 25537?Rat
  • Omim: 604002?Human
  • SwissProt: O75116?Human
  • SwissProt: P70336?Mouse
  • SwissProt: Q62868?Rat
  • Unigene: 58617?Human
  • Unigene: 681743?Human
  • Unigene: 276024?Mouse
  • Unigene: 88642?Rat
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    Synonyms:
  • coiled-coil-containing protein kinase 2 Antibody
  • KIAA0619 Antibody
  • p164 ROCK 2 Antibody
  • p164 ROCK-2 Antibody
  • Rho associated coiled coil containing protein kinase 2 Antibody
  • Rho associated protein kinase 2 Antibody
  • Rho associated, coiled coil containing protein kinase II Antibody
  • Rho kinase 2 Antibody
  • Rho-associated Antibody
  • Rho-associated protein kinase 2 Antibody
  • ROCK 2 Antibody
  • Rock II Antibody
  • ROCK2 Antibody
  • Rock2m Antibody
  • ROCK2_HUMAN Antibody
  • ROK alpha Antibody
  • ROKalpha Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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