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Anti-RNF40 Antibody

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产品名称: Anti-RNF40 Antibody
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Anti-RNF40 Antibody


Anti-RNF40 Antibody  的详细介绍
Name: Anti-RNF40 Antibody
See all RNF40 primary antibodies
Description: Rabbit polyclonal antibody to RNF40
Specificity: The antibody detects endogenous levels of total RNF40 protein.
Applications: WB, IHC
Reactivity: Human
Immunogen: Fusion protein of human RNF40
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 1.3mg / ml
Formulation: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage: Store at -20?C
Function: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes.
Tissue Specificity: Ubiquitously expressed. Expressed at higher level in testis, heart and pancreas, while it is only weakly expressed in lung, skeletal muscle and small intestine.
Sequence Similarities: Belongs to the BRE1 family.
Cellular Location: Nucleus.
Database Links:
  • Entrez Gene: 9810?Human
  • Omim: 607700?Human
  • SwissProt: O75150?Human
  • Unigene: 65238?Human
    		•
    Synonyms:
  • 95 kDa retinoblastoma associated protein Antibody
  • 95 kDa retinoblastoma protein binding protein Antibody
  • 95 kDa retinoblastoma-associated protein Antibody
  • BRE 1B Antibody
  • BRE1 B Antibody
  • BRE1 E3 ubiquitin ligase homolog B Antibody
  • BRE1-B Antibody
  • BRE1B Antibody
  • BRE1B_HUMAN Antibody
  • DKFZp686K191 Antibody
  • E3 ubiquitin protein ligase BRE1B Antibody
  • E3 ubiquitin-protein ligase BRE1B Antibody
  • KIAA0661 Antibody
  • MGC13051 Antibody
  • Rb associated protein Antibody
  • RBP 95 Antibody
  • RBP95 Antibody
  • RING finger protein 40 Antibody
  • Ring finger protein 40 E3 ubiquitin protein ligase Antibody
  • RNF 40 Antibody
  • RNF40 Antibody
  • STARING Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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