产品资料

Anti-RNF31 Antibody

如果您对该产品感兴趣的话,可以
产品名称: Anti-RNF31 Antibody
产品型号:
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

Anti-RNF31 Antibody


Anti-RNF31 Antibody  的详细介绍
Name: Anti-RNF31 Antibody
See all RNF31 primary antibodies
Description: Goat polyclonal antibody to RNF31.
Applications: ELISA, WB
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human RNF31 (C terminal).
Sequence: C-EEVPLGQSIPRRRK
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 µg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173). LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846). Together with otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types (PubMed:23708998).
Tissue Specificity: Expressed in both normal and transformed breast epithelial cell lines.
Post-Translational Modification: Autoubiquitinated. Interaction with OTULIN is required to prevent formation of 'Met-1'-linked polyubiquitin chains.
Cellular Location: Cytoplasm.
Database Links:
  • Entrez Gene: 55072 Human
  • Omim: 612487 Human
  • SwissProt: Q96EP0 Human
  • Unigene: 375217 Human
  • Unigene: 434081 Human
    		•
    Synonyms:
  • E3 ubiquitin protein ligase RNF31 Antibody
  • FLJ10111 Antibody
  • FLJ23501 Antibody
  • HOIL 1L interacting protein Antibody
  • HOIL-1-interacting protein Antibody
  • HOIL1L interacting protein Antibody
  • HOIP Antibody
  • RING finger protein 31 Antibody
  • RNF31 Antibody
  • RNF31/HOIP Antibody
  • RNF31_HUMAN Antibody
  • ZIBRA Antibody
  • Zinc in between ring finger ubiquitin associated domain Antibody
  • Zinc in-between-RING-finger ubiquitin-associated domain protein Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
    产品留言
    标题
    联系人
    联系电话
    内容
    验证码
    点击换一张
    注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
    2.如有必要,请您留下您的详细联系方式!

    沪公网安备 31011202007337号