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Anti-RNF20 Antibody

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产品名称: Anti-RNF20 Antibody
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Anti-RNF20 Antibody


Anti-RNF20 Antibody  的详细介绍
Name: Anti-RNF20 Antibody
See all RNF20 primary antibodies
Description: Rabbit polyclonal antibody to RNF20
Specificity: The antibody detects endogenous levels of total RNF20 protein.
Applications: WB, IHC
Reactivity: Human
Immunogen: Fusion protein corresponding to residues near the C terminal of human ring finger protein 20, E3 ubiquitin protein ligase
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 1.2mg / ml
Formulation: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage: Store at -20?C
Function: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation.
Tissue Specificity: Expressed in the normal brain and also in malignant gliomas (at protein level).
Sequence Similarities: Belongs to the BRE1 family.
Cellular Location: Nucleus.
Database Links:
  • Entrez Gene: 56254?Human
  • Omim: 607699?Human
  • SwissProt: Q5VTR2?Human
  • Unigene: 729085?Human
    		•
    Synonyms:
  • BRE1 Antibody
  • BRE1 A Antibody
  • BRE1 E3 ubiquitin ligase homolog Antibody
  • BRE1-A Antibody
  • BRE1A Antibody
  • BRE1A_HUMAN Antibody
  • E3 ubiquitin-protein ligase BRE1A Antibody
  • hBRE1 Antibody
  • Homolog of S. cerevisiae BRE1 Antibody
  • RING finger protein 20 Antibody
  • Ring finger protein 20 E3 ubiquitin protein ligase Antibody
  • RNF20 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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