产品资料

Anti-RIPK2 Antibody

如果您对该产品感兴趣的话,可以
产品名称: Anti-RIPK2 Antibody
产品型号:
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

Anti-RIPK2 Antibody


Anti-RIPK2 Antibody  的详细介绍
Name: Anti-RIPK2 Antibody
See all RIPK2 primary antibodies
Description: Rabbit polyclonal antibody to RIPK2
Specificity: RIPK2 pAb detects endogenous levels of RIPK2 protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human RIPK2.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~61 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.
Function: Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.
Tissue Specificity: Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.
Sequence Similarities: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Post-Translational Modification: Autophosphorylated. Autophosphorylation at Tyr-474 is necessary for effective NOD2 signaling. Phosphorylated. Phosphorylation at Tyr-381 by Src kinase CSK occurs in a ARHGEF2-dependent manner and is required for NOD2-dependent innate immune activation.
Cellular Location: Cytoplasm.
Database Links:
  • Entrez Gene: 8767?Human
  • Entrez Gene: 192656?Mouse
  • Entrez Gene: 362491?Rat
  • Omim: 603455?Human
  • SwissProt: O43353?Human
  • SwissProt: P58801?Mouse
  • Unigene: 103755?Human
  • Unigene: 112765?Mouse
  • Unigene: 102179?Rat
    		•
    Synonyms:
  • CARD 3 Antibody
  • CARD carrying kinase Antibody
  • CARD containing ICE associated kinase Antibody
  • CARD containing IL 1 beta ICE kinase Antibody
  • CARD containing IL1 beta ICE kinase Antibody
  • CARD containing interleukin 1 beta converting enzyme (ICE) associated kinase Antibody
  • CARD containing interleukin 1 beta converting enzyme associated kinase Antibody
  • CARD-containing IL-1 beta ICE-kinase Antibody
  • CARD-containing interleukin-1 beta-converting enzyme-associated kinase Antibody
  • CARD3 Antibody
  • CARDIAK Antibody
  • CCK Antibody
  • CLARP kinase Antibody
  • GIG 30 Antibody
  • GIG30 Antibody
  • Growth inhibiting gene 30 Antibody
  • Receptor interacting protein (RIP) like interacting caspase like apoptosis regulatory protein (CLARP) kinase Antibody
  • Receptor interacting protein 2 Antibody
  • Receptor interacting serine threonine kinase 2 Antibody
  • Receptor interacting serine/threonine protein kinase 2 Antibody
  • Receptor-interacting protein 2 Antibody
  • Receptor-interacting serine/threonine-protein kinase 2 Antibody
  • RICK Antibody
  • RIP 2 Antibody
  • RIP like interacting CLARP kinase Antibody
  • RIP-2 Antibody
  • RIP-like-interacting CLARP kinase Antibody
  • RIP2 Antibody
  • RIPK 2 Antibody
  • Ripk2 Antibody
  • RIPK2_HUMAN Antibody
  • TNFRSF Antibody
  • Tyrosine-protein kinase RIPK2 Antibody
  • UNQ277/PRO314/PRO34092 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
    产品留言
    标题
    联系人
    联系电话
    内容
    验证码
    点击换一张
    注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
    2.如有必要,请您留下您的详细联系方式!

    沪公网安备 31011202007337号