产品资料

Anti-RICTOR Antibody

如果您对该产品感兴趣的话,可以
产品名称: Anti-RICTOR Antibody
产品型号:
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

Anti-RICTOR Antibody


Anti-RICTOR Antibody  的详细介绍
Name: Anti-RICTOR Antibody
See all RICTOR primary antibodies
Description: Rabbit polyclonal antibody to RICTOR
Applications: WB, IHC, IF
Reactivity: Human
Immunogen: Synthetic peptide contain a sequence corresponding to a region within amino acids 1648 and 1708 of RICTOR
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Purified by antigen-affinity chromatography.
Formulation: Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage: Store at -20?C for long term preservation (recommended). Store at 4?C for short term use.
Function: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.
Sequence Similarities: Belongs to the RICTOR family.
Post-Translational Modification: Phosphorylated by MTOR; when part of mTORC2. Phosphorylated at Thr-1135 by RPS6KB1; phosphorylation of RICTOR inhibits mTORC2 and AKT1 signaling.
Database Links:
  • Entrez Gene: 253260?Human
  • Omim: 609022?Human
  • SwissProt: Q6R327?Human
  • Unigene: 407926?Human
    		•
    Synonyms:
  • AVO3 Antibody
  • AVO3 homolog Antibody
  • DKFZp686B11164 Antibody
  • hAVO3 Antibody
  • KIAA1999 Antibody
  • Likely ortholog of mouse TORC2 specific protein AVO3 (S. cerevisiae) Antibody
  • mAVO3 Antibody
  • MGC39830 Antibody
  • PIA Antibody
  • Pianissimo Antibody
  • Rapamycin insensitive companion of mTOR Antibody
  • Rapamycin-insensitive companion of mTOR Antibody
  • RICTOR Antibody
  • RICTR Antibody
  • RICTR_HUMAN Antibody
  • RPTOR independent companion of MTOR complex 2 Antibody
  • TORC2 specific protein AVO3 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
    产品留言
    标题
    联系人
    联系电话
    内容
    验证码
    点击换一张
    注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
    2.如有必要,请您留下您的详细联系方式!

    沪公网安备 31011202007337号