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Anti-Retinoic Acid Receptor β Antibody

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产品名称: Anti-Retinoic Acid Receptor β Antibody
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Anti-Retinoic Acid Receptor β Antibody


Anti-Retinoic Acid Receptor β Antibody  的详细介绍
Name: Anti-Retinoic Acid Receptor β Antibody
See all Retinoic Acid Receptor β primary antibodies
Description: Rabbit polyclonal antibody to Retinoic Acid Receptor β
Specificity: The antibody detects endogenous levels of total Retinoic Acid Receptor β protein.
Applications: WB, IHC
Reactivity: Human
Immunogen: Synthesized peptide derived from human Retinoic Acid Receptor β.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1.0mg / ml
Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20?C
Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.
Involvement in Disease: Microphthalmia, syndromic, 12: A form of microphthalmia, a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS12 patients manifest variable features, including diaphragmatic hernia, pulmonary hypoplasia, and cardiac abnormalities.
Sequence Similarities: Belongs to the nuclear hormone receptor family. NR1 subfamily.
Cellular Location: Nucleus.
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