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Anti-REL Antibody

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产品名称: Anti-REL Antibody
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简单介绍

Anti-REL Antibody


Anti-REL Antibody  的详细介绍
Name: Anti-REL Antibody
See all c-Rel primary antibodies
Description: Goat polyclonal antibody to REL.
Applications: ELISA, WB, IHC
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human REL (internal region).
Sequence: NDLNASNACIYN
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 μg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.
Cellular Location: Nucleus.
Database Links:
  • Entrez Gene: 5966?Human
  • Omim: 164910?Human
  • SwissProt: Q04864?Human
  • Unigene: 631886?Human
    		•
    Synonyms:
  • Avian reticuloendotheliosis Antibody
  • C REL Antibody
  • C Rel protein Antibody
  • c Rel proto oncogene protein Antibody
  • c-Rel Antibody
  • Oncogene REL Antibody
  • Oncogene REL avian reticuloendotheliosis Antibody
  • Proto-oncogene c-Rel Antibody
  • REL Antibody
  • REL_HUMAN Antibody
  • v rel avian reticuloendotheliosis viral oncogene homolog Antibody
  • v rel reticuloendotheliosis viral oncogene homolog Antibody
  • V rel reticuloendotheliosis viral oncogene homolog (avian) Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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