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Anti-RCC1 Antibody

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产品名称: Anti-RCC1 Antibody
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简单介绍

Anti-RCC1 Antibody


Anti-RCC1 Antibody  的详细介绍
Name: Anti-RCC1 Antibody
See all RCC1 primary antibodies
Description: Rabbit polyclonal antibody to RCC1
Specificity: The antibody detects endogenous levels of total RCC1 protein.
Applications: WB, IHC
Reactivity: Human
Immunogen: Synthesized peptide derived from human RCC1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1.0mg / ml
Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20?C
Function: Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo-cytoplasmic transport, mitosis and nuclear-envelope assembly.
Post-Translational Modification: N-terminal methylation by METTL11A/NTM1 is required for binding double-stranded DNA and stable chromatin association. Di- and trimethylation produce a permanent positive charge on the amino group, which facilitates electrostatic binding to the phosphate groups on DNA, while inhibiting histone-binding. Methylated tail helps retain RCC1 on chromosomes during nucleotide exchange on Ran.
Cellular Location: Nucleus. Cytoplasm.

Becomes dispersed throughout the cytoplasm during mitosis.
Database Links:
  • Entrez Gene: 1104?Human
  • Omim: 179710?Human
  • SwissProt: P18754?Human
  • Unigene: 469723?Human
    		•
    Synonyms:
  • Cell cycle regulatory protein Antibody
  • CHC 1 Antibody
  • CHC1 Antibody
  • Chromosome condensation 1 Antibody
  • Chromosome condensation protein 1 Antibody
  • Guanine nucleotide releasing protein Antibody
  • HERC2 Antibody
  • Ran GEF Antibody
  • RanGEF Antibody
  • RCC 1 Antibody
  • RCC1 Antibody
  • RCC1 I Antibody
  • RCC1_HUMAN Antibody
  • Regulator of chromosome condensation Antibody
  • Regulator of chromosome condensation 1 Antibody
  • SHEP1 Antibody
  • SNHG3 RCC1 Antibody
  • SNHG3 RCC1 readthrough transcript Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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