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Anti-RBX1 Antibody

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产品名称: Anti-RBX1 Antibody
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简单介绍

Anti-RBX1 Antibody


Anti-RBX1 Antibody  的详细介绍
Name: Anti-RBX1 Antibody
See all RBX1 primary antibodies
Description: Rabbit polyclonal antibody to RBX1
Specificity: The antibody detects endogenous levels of total RBX1 protein.
Applications: WB, IHC
Reactivity: Human, Mouse
Immunogen: Fusion protein of human RBX1
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 1mg / ml
Formulation: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage: Store at -20?C
Function: E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (PubMed:27565346). The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41. In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM.
Tissue Specificity: Widely expressed.
Sequence Similarities: Belongs to the RING-box family.
Cellular Location: Cytoplasm. Nucleus.
Database Links:
  • Entrez Gene: 9978?Human
  • Entrez Gene: 56438?Mouse
  • Omim: 603814?Human
  • SwissProt: P62877?Human
  • SwissProt: P62878?Mouse
  • Unigene: 474949?Human
  • Unigene: 29405?Mouse
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    Synonyms:
  • BA554C12.1 Antibody
  • E3 ubiquitin-protein ligase RBX1 Antibody
  • FLJ60363 Antibody
  • MGC13357 Antibody
  • MGC1481 Antibody
  • OTTHUMP00000028983 Antibody
  • Protein ZYP Antibody
  • Rbx 1 Antibody
  • Rbx1 Antibody
  • RBX1_HUMAN Antibody
  • Regulator of cullins 1 Antibody
  • Ring box 1 Antibody
  • Ring box 1 E3 ubiquitin protein ligase Antibody
  • RING box protein 1 Antibody
  • RING finger protein Antibody
  • RING finger protein 75 Antibody
  • RING-box protein 1 Antibody
  • Ringbox protein 1 Antibody
  • RNF 75 Antibody
  • RNF75 Antibody
  • ROC 1 Antibody
  • ROC1 Antibody
  • ZYP protein Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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