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Anti-RBM4 Antibody

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产品名称: Anti-RBM4 Antibody
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Anti-RBM4 Antibody


Anti-RBM4 Antibody  的详细介绍
Name: Anti-RBM4 Antibody
See all RBM4 primary antibodies
Description: Rabbit polyclonal antibody to RBM4
Applications: WB, IHC, IF
Reactivity: Human
Immunogen: Synthetic peptide contain a sequence corresponding to a region within amino acids 304 and 316 (Q9BWF3) of RBM4
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Purified by antigen-affinity chromatography.
Formulation: Supplied in 1XPBS, 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage: Store at -20?C for long term preservation (recommended). Store at 4?C for short term use.
Function: RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro.
Tissue Specificity: Expressed in the cerebellum. Expressed in neurons and glial cells, including layers II neurons in the frontal cortex and CA1 pyramidal neurons in the hippocampus. Expressed in heart, liver, pancreas, skeletal muscle, placenta, primary fibroblasts and peripheral blood monocytes (at protein level). Ubiquitously expressed. Highly expressed in heart, placenta and skeletal muscle. Weakly expressed in pancreas, kidney, liver, lung and brain.
Post-Translational Modification: Phosphorylation on Ser-309 is induced upon cell muscle differentiation (By similarity). Phosphorylated. Phosphorylated in vitro on Ser-309 by SRPK1. Phosphorylation on Ser-309 is induced upon cell stress signaling, which alters its subcellular localization and may modulate its activity on IRES-mediated mRNA translation.
Cellular Location: Nucleus. Nucleus > Nucleolus. Nucleus speckle. Cytoplasm. Cytoplasmic granule.

Undergoes continuous nucleocytoplasmic shuttling. Upon nuclear import colocalizes with SR proteins in nuclear speckles. Arsenite stress-induced phosphorylation increases its subcellular relocalization from the nucleus to the cytoplasm and to cytoplasmic stress granules (SG) via a p38 MAPK signaling pathway. Primarily localized in nucleus and nucleoli under cell growth conditions and accumulated in the cytoplasm and cytoplasm perinuclear granules upon muscle cell differentiation.
Database Links:
  • Entrez Gene: 5936?Human
  • Omim: 602571?Human
  • SwissProt: Q9BWF3?Human
  • Unigene: 533712?Human
    		•
    Synonyms:
  • dkfzp547k0918 Antibody
  • hLark Antibody
  • lark Antibody
  • Lark homolog Antibody
  • lark homologue Antibody
  • mgc75138 Antibody
  • RBM4 Antibody
  • rbm4 lark Antibody
  • RBM4_HUMAN Antibody
  • RNA binding motif 4 Antibody
  • RNA binding motif 4a Antibody
  • RNA-binding motif protein 4 Antibody
  • RNA-binding motif protein 4a Antibody
  • RNA-binding protein 4 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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