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Anti-RASSF1 Antibody

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产品名称: Anti-RASSF1 Antibody
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Anti-RASSF1 Antibody


Anti-RASSF1 Antibody  的详细介绍
Name: Anti-RASSF1 Antibody
See all RASSF1 primary antibodies
Description: Rabbit polyclonal antibody to RASSF1
Specificity: The antibody detects endogenous level of total RASSF1 protein.
Applications: WB, IHC, IF
Reactivity: Human
Immunogen: Recombinant protein of human RASSF1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were purified by affinity purification using immunogen.
Concentration: 1.0mg / ml
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20?C
Function: Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.
Tissue Specificity: Isoform A and isoform C are ubiquitously expressed in all tissues tested, however isoform A is absent in many corresponding cancer cell lines. Isoform B is mainly expressed in hematopoietic cells.
Cellular Location: Cytoplasm > Cytoskeleton. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Cytoplasm > Cytoskeleton > Spindle. Cytoplasm > Cytoskeleton > Spindle pole. Nucleus.

Localizes to cytoplasmic microtubules during interphase, to bipolar centrosomes associated with microtubules during prophase, to spindle fibers and spindle poles at metaphase and anaphase, to the midzone during early telophase, and to the midbody in late telophase in cells. Colocalizes with MDM2 in the nucleus.
Database Links:
  • Entrez Gene: 11186?Human
  • Omim: 605082?Human
  • SwissProt: Q9NS23?Human
  • Unigene: 476270?Human
    		•
    Synonyms:
  • 123F2 Antibody
  • Cardiac specific ras association domain family 1 protein Antibody
  • cardiac-specific ras association domain family 1 protein, 123F2 Antibody
  • NORE2A Antibody
  • OTTHUMP00000195503 Antibody
  • OTTHUMP00000195504 Antibody
  • OTTHUMP00000195505 Antibody
  • OTTHUMP00000195507 Antibody
  • Pancreas specific ras association domain family 1 protein Antibody
  • Ras association (RalGDS/AF 6) domain family member 1 Antibody
  • Ras association domain-containing protein 1 Antibody
  • RASF1_HUMAN Antibody
  • RASSF1 Antibody
  • RASSF1A Antibody
  • RDA32 Antibody
  • REH3P21 Antibody
  • Tumor suppressor protein RDA32 Antibody
  • WUGSC:H_LUCA12.5 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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