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Anti-RASGRP4 Antibody

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产品名称: Anti-RASGRP4 Antibody
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Anti-RASGRP4 Antibody


Anti-RASGRP4 Antibody  的详细介绍
Name: Anti-RASGRP4 Antibody
See all RASGRP4 primary antibodies
Description: Rabbit polyclonal antibody to RASGRP4
Applications: WB, IHC, IF
Reactivity: Human
Immunogen: Synthetic peptide contain a sequence corresponding to a region within amino acids 108 and 170 of Human RASGRP4
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Purified by antigen-affinity chromatography.
Formulation: Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage: Store at -20?C for long term preservation (recommended). Store at 4?C for short term use.
Function: Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation.
Tissue Specificity: Expressed by mast cells and their progenitors (at protein level). Specifically expressed in mononuclear leukocytes. Highly expressed in myeloid cells compared to lymphoid cells. Also detected in heart, skeletal muscle, spleen, liver, placenta and lung. Not detected in brain. Isoform 1 is the major isoform in normal individuals. Isoform 2 is more significantly expressed in a patient with asthma. Isoform 3 is more significantly expressed in a patient with asthma and a mastocytosis patient.
Sequence Similarities: Belongs to the RASGRP family.
Cellular Location: Cytoplasm. Cell membrane.

Recruited to membranes upon activation by DAG.
Database Links:
  • Entrez Gene: 115727?Human
  • Omim: 607320?Human
  • SwissProt: Q8TDF6?Human
  • Unigene: 130434?Human
    		•
    Synonyms:
  • GRP4_HUMAN Antibody
  • Guanyl nucleotide releasing protein 4 Antibody
  • RAS guanyl releasing protein 4 Antibody
  • RAS guanyl-releasing protein 4 Antibody
  • RASGRP 4 Antibody
  • RASGRP4 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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