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Anti-RAN Antibody

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产品名称: Anti-RAN Antibody
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简单介绍

Anti-RAN Antibody


Anti-RAN Antibody  的详细介绍
Name: Anti-RAN Antibody
See all RAN primary antibodies
Description: Goat polyclonal antibody to RAN.
Applications: ELISA, WB
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide corresponding to Human RAN (C terminal).
Sequence: C-YEHDLEVAQTTALP
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 µg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation.
Sequence Similarities: Belongs to the small GTPase superfamily. Ran family.
Post-Translational Modification: Acetylation by KAT5 at Lys-134 is increased during mitosis, impairs RANGRF binding and enhances RCC1 binding.
Cellular Location: Nucleus. Nucleus envelope. Cytoplasm > Cytosol. Cytoplasm. Melanosome.

Predominantly nuclear during interphase. Becomes dispersed throughout the cytoplasm during mitosis (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (By similarity).
Database Links:
  • Entrez Gene: 5901 Human
  • Entrez Gene: 100045999 Mouse
  • Entrez Gene: 19384 Mouse
  • Entrez Gene: 84509 Rat
  • Omim: 601179 Human
  • SwissProt: P62826 Human
  • SwissProt: P62827 Mouse
  • SwissProt: P62828 Rat
  • Unigene: 10842 Human
  • Unigene: 297440 Mouse
  • Unigene: 386831 Mouse
  • Unigene: 107698 Rat
    		•
    Synonyms:
  • Androgen receptor associated protein 24 Antibody
  • Androgen receptor-associated protein 24 Antibody
  • ARA 24 Antibody
  • ARA24 Antibody
  • Gsp1 Antibody
  • GTP binding nuclear protein RAN Antibody
  • GTP-binding nuclear protein Ran Antibody
  • GTPase Ran Antibody
  • Guanosine triphosphatase Ran Antibody
  • LPS Antibody
  • Member RAS oncogene family Antibody
  • OK/SW-cl.81 Antibody
  • Ran Antibody
  • RAN member RAS oncogene family Antibody
  • RanGTPase Antibody
  • RAN_HUMAN Antibody
  • Ras like protein TC4 Antibody
  • Ras related nuclear protein Antibody
  • Ras-like protein TC4 Antibody
  • Ras-related nuclear protein Antibody
  • RASL2 8 Antibody
  • TC 4 Antibody
  • TC4 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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