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Anti-RAN Antibody

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简单介绍

Anti-RAN Antibody


Anti-RAN Antibody  的详细介绍
Name: Anti-RAN Antibody
See all RAN primary antibodies
Description: Rabbit polyclonal antibody to RAN.
Applications: WB, IHC, IF, IP, RIP
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200, IP: 1:20 - 1:50, RIP: 1:20 - 1:50.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human RAN.
Protein Length: 216
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensure the directionality of the transport.
Tissue Specificity: Expressed in a variety of tissues.
Sequence Similarities: Belongs to the small GTPase superfamily. Ran family.
Cellular Location: Nucleus. Nucleus envelope. Cytoplasm. Melanosome.

Predominantly nuclear during interphase. Becomes dispersed throughout the cytoplasm during mitosis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Database Links:
  • Entrez Gene: 5901?Human
  • Entrez Gene: 100045999?Mouse
  • Entrez Gene: 19384?Mouse
  • Entrez Gene: 84509?Rat
  • Omim: 601179?Human
  • SwissProt: P62826?Human
  • SwissProt: P62827?Mouse
  • SwissProt: P62828?Rat
  • Unigene: 10842?Human
  • Unigene: 297440?Mouse
  • Unigene: 386831?Mouse
  • Unigene: 107698?Rat
    		•
    Synonyms:
  • Androgen receptor associated protein 24 Antibody
  • Androgen receptor-associated protein 24 Antibody
  • ARA 24 Antibody
  • ARA24 Antibody
  • Gsp1 Antibody
  • GTP binding nuclear protein RAN Antibody
  • GTP-binding nuclear protein Ran Antibody
  • GTPase Ran Antibody
  • Guanosine triphosphatase Ran Antibody
  • LPS Antibody
  • Member RAS oncogene family Antibody
  • OK/SW-cl.81 Antibody
  • Ran Antibody
  • RAN member RAS oncogene family Antibody
  • RanGTPase Antibody
  • RAN_HUMAN Antibody
  • Ras like protein TC4 Antibody
  • Ras related nuclear protein Antibody
  • Ras-like protein TC4 Antibody
  • Ras-related nuclear protein Antibody
  • RASL2 8 Antibody
  • TC 4 Antibody
  • TC4 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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