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Anti-RAD9A Antibody

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产品名称: Anti-RAD9A Antibody
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简单介绍

Anti-RAD9A Antibody


Anti-RAD9A Antibody  的详细介绍
Name: Anti-RAD9A Antibody
See all RAD9A primary antibodies
Description: Goat polyclonal antibody to RAD9A.
Applications: ELISA, WB, EIA
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human RAD9A (C terminal).
Sequence: C-QGPSPVLAEDSEGE
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 µg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex.
Sequence Similarities: Belongs to the rad9 family.
Post-Translational Modification: Constitutively phosphorylated on serine and threonine amino acids in absence of DNA damage. Hyperphosphorylated by PRKCD and ABL1 upon DNA damage. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex.
Cellular Location: Nucleus.
Database Links:
  • Entrez Gene: 5883 Human
  • Omim: 603761 Human
  • SwissProt: Q99638 Human
  • Unigene: 655354 Human
    		•
    Synonyms:
  • Cell cycle checkpoint control protein Antibody
  • Cell cycle checkpoint control protein RAD9A Antibody
  • DNA repair exonuclease rad9 homolog A Antibody
  • hRAD 9 Antibody
  • hRAD9 Antibody
  • Rad 9 Antibody
  • RAD 9A Antibody
  • Rad9 Antibody
  • RAD9 (S pombe) homolog Antibody
  • RAD9 homolog Antibody
  • RAD9 homolog A Antibody
  • Rad9a Antibody
  • RAD9A_HUMAN Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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