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Anti-RAD Antibody

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产品名称: Anti-RAD Antibody
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Anti-RAD Antibody


Anti-RAD Antibody  的详细介绍
Name: Anti-RAD Antibody
See all RAD primary antibodies
Description: Rabbit polyclonal antibody to RAD
Specificity: The antibody detects endogenous levels of total RAD protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Synthesized peptide derived from internal of human RAD.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1.0mg / ml
Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20?C
Function: May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.
Tissue Specificity: Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans.
Sequence Similarities: Belongs to the small GTPase superfamily. RGK family.
Cellular Location: Cell membrane.
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