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Anti-ATG4A Antibody

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产品名称: Anti-ATG4A Antibody
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Anti-ATG4A Antibody


Anti-ATG4A Antibody  的详细介绍
Name: Anti-ATG4A Antibody
See all ATG4A primary antibodies
Description: Rabbit polyclonal antibody to ATG4A
Specificity: The antibody detects endogenous level of total ATG4A protein.
Applications: WB, IHC, IP
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human ATG4A.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were purified by affinity purification using immunogen.
Concentration: 1.0mg / ml
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20?C
Function: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Tissue Specificity: Widely expressed, at a low level, and the highest expression is observed in skeletal muscle and brain. Also detected in fetal liver.
Sequence Similarities: Belongs to the peptidase C54 family.
Cellular Location: Cytoplasm.
Database Links:
  • Entrez Gene: 115201?Human
  • Entrez Gene: 666468?Mouse
  • Omim: 300663?Human
  • SwissProt: Q8WYN0?Human
  • SwissProt: Q8C9S8?Mouse
  • Unigene: 8763?Human
  • Unigene: 102230?Mouse
  • Unigene: 393320?Mouse
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    Synonyms:
  • AI627006 Antibody
  • APG4 autophagy 4 homolog A Antibody
  • Apg4a Antibody
  • ATG4 autophagy related 4 homolog A Antibody
  • ATG4 autophagy related 4 homolog A (S. cerevisiae) Antibody
  • ATG4A Antibody
  • Atg4al Antibody
  • ATG4A_HUMAN Antibody
  • AUT like 2 cysteine endopeptidase Antibody
  • AUT-like 2 cysteine endopeptidase Antibody
  • Autl2 Antibody
  • Autophagin 2 Antibody
  • Autophagin-2 Antibody
  • Autophagy related 4A cysteine peptidase Antibody
  • Autophagy related cysteine endopeptidase 2 Antibody
  • Autophagy related protein 4 homolog A Antibody
  • Autophagy-related cysteine endopeptidase 2 Antibody
  • Autophagy-related protein 4 homolog A Antibody
  • AV169859 Antibody
  • Cysteine protease ATG4A Antibody
  • hAPG4A Antibody
  • MGC107179 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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