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Anti-ATG3 Antibody

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产品名称: Anti-ATG3 Antibody
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Anti-ATG3 Antibody


Anti-ATG3 Antibody  的详细介绍
Name: Anti-ATG3 Antibody
See all ATG3 primary antibodies
Description: Rabbit polyclonal antibody to ATG3.
Applications: WB, IHC
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human ATG3.
Protein Length: 314
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.
Tissue Specificity: Widely expressed, with a highest expression in heart, skeletal muscle, kidney, liver and placenta.
Sequence Similarities: Belongs to the ATG3 family.
Post-Translational Modification: Conjugated to ATG12 at Lys-243. ATG12-conjugation plays a role in regulation of mitochondrial homeostasis and cell death, while it is not involved in PE-conjugation to ATG8-like proteins and autophagy.
Cellular Location: Cytoplasm.
Database Links:
  • Entrez Gene: 64422?Human
  • Entrez Gene: 67841?Mouse
  • Entrez Gene: 171415?Rat
  • Omim: 609606?Human
  • SwissProt: Q9NT62?Human
  • SwissProt: Q9CPX6?Mouse
  • SwissProt: Q6AZ50?Rat
  • Unigene: 477126?Human
  • Unigene: 41775?Mouse
  • Unigene: 3084?Rat
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    Synonyms:
  • 2610016C12Rik Antibody
  • Apg 3 Antibody
  • Apg3 Antibody
  • APG3 autophagy 3 like Antibody
  • APG3 like Antibody
  • APG3, S. cerevisiae, homolog of Antibody
  • APG3-like Antibody
  • APG3L Antibody
  • Apg3p Antibody
  • ATG 3 Antibody
  • ATG3 Antibody
  • ATG3 autophagy related 3 homolog Antibody
  • ATG3 autophagy related 3 homolog (S. cerevisiae) Antibody
  • ATG3_HUMAN Antibody
  • Autophagy 3, S. cerevisiae, homolog of Antibody
  • Autophagy Apg3p/Aut1p like Antibody
  • autophagy related 3 Antibody
  • Autophagy related protein 3 Antibody
  • Autophagy-related protein 3 Antibody
  • DKFZp564M1178 Antibody
  • FLJ22125 Antibody
  • hApg3 Antibody
  • MGC15201 Antibody
  • OTTHUMP00000214547 Antibody
  • OTTHUMP00000214548 Antibody
  • PC3 96 Antibody
  • Protein PC3-96 Antibody
  • Ubiquitin-like-conjugating enzyme ATG3 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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