产品资料

Anti-ATG16L1 Antibody

如果您对该产品感兴趣的话,可以
产品名称: Anti-ATG16L1 Antibody
产品型号:
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

Anti-ATG16L1 Antibody


Anti-ATG16L1 Antibody  的详细介绍
Name: Anti-ATG16L1 Antibody
See all ATG16L1 primary antibodies
Description: Rabbit polyclonal antibody to ATG16L1
Specificity: The antibody detects endogenous level of total ATG16L1 protein.
Applications: WB, IHC, IF, IP
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human ATG16L1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were purified by affinity purification using immunogen.
Concentration: 1.0mg / ml
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20?C
Function: Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:24553140, PubMed:23376921, PubMed:24954904, PubMed:27273576, PubMed:23392225). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966).
Involvement in Disease: Inflammatory bowel disease 10: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
Sequence Similarities: Belongs to the WD repeat ATG16 family.
Post-Translational Modification: Proteolytic cleavage by activated CASP3 leads to degradation and may regulate autophagy upon cellular stress and apoptotic stimuli.
Cellular Location: Cytoplasm. Preautophagosomal structure membrane.

Recruited to omegasomes membranes by WIPI2. Omegasomes are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures. Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5. Localizes also to discrete punctae along the ciliary axoneme.
Database Links:
  • Entrez Gene: 55054?Human
  • Entrez Gene: 77040?Mouse
  • Entrez Gene: 363278?Rat
  • Omim: 610767?Human
  • SwissProt: Q676U5?Human
  • SwissProt: Q8C0J2?Mouse
  • Unigene: 529322?Human
  • Unigene: 272972?Mouse
  • Unigene: 456099?Mouse
    		•
    Synonyms:
  • A16L1_HUMAN Antibody
  • APG16 like 1 Antibody
  • APG16-like 1 Antibody
  • APG16L Antibody
  • APG16L beta Antibody
  • ATG16 autophagy related 16 like 1 Antibody
  • ATG16 autophagy related 16-like 1 (S. cerevisiae) Antibody
  • ATG16A Antibody
  • ATG16L Antibody
  • ATG16L1 Antibody
  • Autophagy related protein 16 1 Antibody
  • Autophagy-related protein 16-1 Antibody
  • FLJ00045 Antibody
  • FLJ10035 Antibody
  • FLJ10828 Antibody
  • FLJ22677 Antibody
  • IBD10 Antibody
  • OTTHUMP00000164391 Antibody
  • OTTHUMP00000164393 Antibody
  • OTTHUMP00000165876 Antibody
  • OTTHUMP00000165877 Antibody
  • WD repeat domain 30 Antibody
  • WDR30 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
    产品留言
    标题
    联系人
    联系电话
    内容
    验证码
    点击换一张
    注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
    2.如有必要,请您留下您的详细联系方式!

    沪公网安备 31011202007337号