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Anti-ATG13 Antibody

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产品名称: Anti-ATG13 Antibody
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Anti-ATG13 Antibody


Anti-ATG13 Antibody  的详细介绍
Name: Anti-ATG13 Antibody
See all ATG13 primary antibodies
Description: Rabbit polyclonal antibody to ATG13
Specificity: ATG13 pAb detects endogenous levels of ATG13 protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human ATG13.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 57 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.
Function: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
Sequence Similarities: Belongs to the ATG13 family. Metazoan subfamily.
Post-Translational Modification: Phosphorylated by ULK1, ULK2 and mTOR. Phosphorylation status depends on nutrient-rich conditions; dephosphorylated during starvation or following treatment with rapamycin. ULK1-mediated phosphorylation of ATG13 at Ser-355 is required for efficient clearance of depolarized mitochondria.
Cellular Location: Cytoplasm > Cytosol. Preautophagosomal structure.

Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation.
Database Links:
  • Entrez Gene: 9776?Human
  • Entrez Gene: 51897?Mouse
  • Entrez Gene: 362164?Rat
  • SwissProt: O75143?Human
  • SwissProt: Q91YI1?Mouse
  • Unigene: 127403?Human
  • Unigene: 28492?Mouse
  • Unigene: 98797?Rat
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    Synonyms:
  • ATG13 Antibody
  • ATG13 autophagy related 13 homolog (S. cerevisiae) Antibody
  • ATG13_HUMAN Antibody
  • Autophagy related 13 Antibody
  • Autophagy related protein 13 Antibody
  • Autophagy-related protein 13 Antibody
  • FLJ20698 Antibody
  • KIAA0652 Antibody
  • OTTHUMP00000233321 Antibody
  • OTTHUMP00000233322 Antibody
  • OTTHUMP00000233323 Antibody
  • OTTHUMP00000233324 Antibody
  • OTTHUMP00000233325 Antibody
  • OTTHUMP00000233326 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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