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Anti-ATF4 (R239) Antibody

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产品名称: Anti-ATF4 (R239) Antibody
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Anti-ATF4 (R239) Antibody


Anti-ATF4 (R239) Antibody  的详细介绍
Name: Anti-ATF4 (R239) Antibody
See all ATF4 primary antibodies
Description: Rabbit polyclonal antibody to ATF4 (R239)
Specificity: ATF4 (R239) pAb detects endogenous levels of ATF4 protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 200-250 of Human ATF4.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 42 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic reticulum (ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors (PubMed:26086088).
Sequence Similarities: Belongs to the bZIP family.
Post-Translational Modification: Ubiquitinated by SCF(BTRC) in response to mTORC1 signal, followed by proteasomal degradation and leading to down-regulate expression of SIRT4.
Cellular Location: Cytoplasm. Cell membrane. Nucleus. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome.

Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity). Colocalizes with NEK6 at the centrosome (PubMed:20873783).
Database Links:
  • Entrez Gene: 468?Human
  • Entrez Gene: 11911?Mouse
  • Entrez Gene: 79255?Rat
  • Omim: 604064?Human
  • SwissProt: P18848?Human
  • SwissProt: Q06507?Mouse
  • SwissProt: Q9ES19?Rat
  • Unigene: 496487?Human
  • Unigene: 641?Mouse
  • Unigene: 2423?Rat
    		•
    Synonyms:
  • Activating transcription factor 4 Antibody
  • ATF 4 Antibody
  • ATF-4 Antibody
  • ATF4 Antibody
  • ATF4 protein Antibody
  • ATF4_HUMAN Antibody
  • cAMP-dependent transcription factor ATF-4 Antibody
  • cAMP-responsive element-binding protein 2 Antibody
  • CREB 2 Antibody
  • CREB-2 Antibody
  • CREB2 Antibody
  • Cyclic AMP dependent transcription factor ATF 4 Antibody
  • Cyclic AMP response element binding protein 2 Antibody
  • Cyclic AMP-dependent transcription factor ATF-4 Antibody
  • Cyclic AMP-responsive element-binding protein 2 Antibody
  • DNA binding protein TAXREB67 Antibody
  • DNA-binding protein TAXREB67 Antibody
  • Tax Responsive Enhancer Element B67 Antibody
  • Tax-responsive enhancer element-binding protein 67 Antibody
  • TaxREB67 Antibody
  • TXREB Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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