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Anti-ASK1 (phospho-S966) Antibody

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产品名称: Anti-ASK1 (phospho-S966) Antibody
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Anti-ASK1 (phospho-S966) Antibody


Anti-ASK1 (phospho-S966) Antibody  的详细介绍
Name: Anti-ASK1 (phospho-S966) Antibody
See all ASK1 primary antibodies
Description: Rabbit polyclonal antibody to ASK1 (phospho-S966)
Specificity: p-ASK1 (S966) pAb detects endogenous levels of ASK1protein only when phosphorylated atSer966.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic phosphopeptide derived from human ASK1 around the phosphorylation site of Serine 966.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 155 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).
Tissue Specificity: Abundantly expressed in heart and pancreas.
Sequence Similarities: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Post-Translational Modification: Phosphorylated at Thr-838 through autophosphorylation and by MAP3K6/ASK2 which leads to activation. Thr-838 is dephosphorylated by PPP5C. Ser-83 and Ser-1033 are inactivating phosphorylation sites, the former of which is phosphorylated by AKT1 and AKT2. Phosphorylated at Ser-966 which induces association of MAP3K5/ASK1 with the 14-3-3 family proteins and suppresses MAP3K5/ASK1 activity. Calcineurin (CN) dephosphorylates this site. Also dephosphorylated and activated by PGAM5.
Cellular Location: Cytoplasm. Endoplasmic reticulum.

Interaction with 14-3-3 proteins alters the distribution of MAP3K5/ASK1 and restricts it to the perinuclear endoplasmic reticulum region.
Database Links:
  • Entrez Gene: 4217?Human
  • Entrez Gene: 26408?Mouse
  • Entrez Gene: 365057?Rat
  • Omim: 602448?Human
  • SwissProt: Q99683?Human
  • SwissProt: O35099?Mouse
  • Unigene: 186486?Human
  • Unigene: 6595?Mouse
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    Synonyms:
  • Apoptosis signal regulating kinase 1 Antibody
  • Apoptosis signal-regulating kinase 1 Antibody
  • ASK 1 Antibody
  • ASK-1 Antibody
  • ASK1 Antibody
  • M3K5 Antibody
  • M3K5_HUMAN Antibody
  • MAP/ERK kinase kinase 5 Antibody
  • MAP3K5 Antibody
  • MAPK/ERK kinase kinase 5 Antibody
  • MAPKKK5 Antibody
  • MEK kinase 5 Antibody
  • MEKK 5 Antibody
  • MEKK5 Antibody
  • Mitogen activated protein kinase kinase kinase 5 Antibody
  • Mitogen-activated protein kinase kinase kinase 5 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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