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Anti-ARSB Antibody

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简单介绍

Anti-ARSB Antibody


Anti-ARSB Antibody  的详细介绍
Name: Anti-ARSB Antibody
See all ARSB primary antibodies
Description: Goat polyclonal antibody to ARSB.
Applications: ELISA, WB, IHC
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human ARSB (internal region).
Sequence: C-KLARGHTNGTKPLD
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 μg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:19306108). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (PubMed:19306108). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity).
Involvement in Disease: Mucopolysaccharidosis 6: An autosomal recessive lysosomal storage disease characterized by intracellular accumulation of dermatan sulfate. Clinical features can include abnormal growth, short stature, stiff joints, skeletal malformations, corneal clouding, hepatosplenomegaly, and cardiac abnormalities. A wide variation in clinical severity is observed.

Multiple sulfatase deficiency: A clinically and biochemically heterogeneous disorder caused by the simultaneous impairment of all sulfatases, due to defective post-translational modification and activation. It combines features of individual sulfatase deficiencies such as metachromatic leukodystrophy, mucopolysaccharidosis, chondrodysplasia punctata, hydrocephalus, ichthyosis, neurologic deterioration and developmental delay.
Sequence Similarities: Belongs to the sulfatase family.
Post-Translational Modification: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. This post-translational modification is severely defective in multiple sulfatase deficiency (MSD).
Cellular Location: Lysosome. Cell surface.
Database Links:
  • Entrez Gene: 411?Human
  • Omim: 611542?Human
  • SwissProt: P15848?Human
  • Unigene: 149103?Human
  • Unigene: 604199?Human
    		•
    Synonyms:
  • ARSB Antibody
  • ARSB_HUMAN Antibody
  • Arylsulfatase B Antibody
  • ArylsulfataseB Antibody
  • ASB Antibody
  • G4S Antibody
  • MPS6 Antibody
  • N acetylgalactosamine 4 sulfatase Antibody
  • N-acetylgalactosamine-4-sulfatase Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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