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Anti-ARF1 Antibody

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产品名称: Anti-ARF1 Antibody
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简单介绍

Anti-ARF1 Antibody


Anti-ARF1 Antibody  的详细介绍
Name: Anti-ARF1 Antibody
See all ARF1 primary antibodies
Description: Rabbit polyclonal antibody to ARF1.
Applications: WB, IHC
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:100.
Reactivity: Human, Mouse, Rat
Immunogen: A synthetic peptide of human ARF1.
Protein Length: 181
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).
Sequence Similarities: Belongs to the small GTPase superfamily. Arf family.
Post-Translational Modification: Demyristoylated by S.flexneri cysteine protease IpaJ which cleaves the peptide bond between N-myristoylated Gly-2 and Asn-3.
Cellular Location: Golgi apparatus. Cytoplasm > Perinuclear region. Cell junction > Synapse > Synaptosome. Cell junction > Synapse > Postsynaptic cell membrane > Postsynaptic density. Membrane.
Database Links:
  • Entrez Gene: 375?Human
  • Entrez Gene: 11840?Mouse
  • Entrez Gene: 64310?Rat
  • Omim: 103180?Human
  • SwissProt: P84077?Human
  • SwissProt: P84078?Mouse
  • SwissProt: P84079?Rat
  • Unigene: 286221?Human
  • Unigene: 371546?Mouse
  • Unigene: 6836?Mouse
  • Unigene: 93735?Rat
    		•
    Synonyms:
  • ADP Ribosylation Factor 1 Antibody
  • ADP-ribosylation factor 1 Antibody
  • ARF 1 Antibody
  • ARF1 Antibody
  • ARF1_HUMAN Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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